BMS2047 Pharmacology - On demand Lecture 3 Gout PDF

Summary

This lecture covers the topic of gout, inflammation, and anti-inflammatories. It details the recruitment of immune cells, secretion of prostaglandins and cytokines, and activation of osteoclasts leading to demineralization. Various medications and their mechanisms are also discussed.

Full Transcript

Inflammation and Antiinflammatories Dr Penny Lympany [email protected] 28AY04 Gout Lecture bite 3 Gout Recruitment of immune cells Secretion of prostaglandins & cytokines Activation of osteoclasts → demineralisation Gout and its progression Recruitment of immune cells Secretion of prostaglandin...

Inflammation and Antiinflammatories Dr Penny Lympany [email protected] 28AY04 Gout Lecture bite 3 Gout Recruitment of immune cells Secretion of prostaglandins & cytokines Activation of osteoclasts → demineralisation Gout and its progression Recruitment of immune cells Secretion of prostaglandins & cytokines Activation of osteoclasts → demineralisation Gout and its progression Gout Hypoxanthine OH OH N N N N N N HO Xanthin e N N HO OH N Uric N acid OH N N OH N N N N Allopurinol Acute attacks: NSAIDs - NOT aspirin colchicine – microtubule inhibitor Long-term control: uricosuric drugs increase uric acid excretion e.g. probenecid allopurinol - xanthine oxidase inhibitor Don’t forget to:  Check out the case study  Look at the covid question and start to brainstorm how you would approach it. We will be looking at this next week in the tutorial sessions.  Spend time reflecting on your week, what questions you have and have you been productive with your time. To post on the discussion board click here References GENERAL: Rang & Dales Pharmacology (2016) 8th Edition, Elsevier. Neal (2016) Medical Pharmacology at a Glance 8th Edn (especially for revision) IN MORE DETAIL: Serhan, C., Chiang, N. & Van Dyke, T. (2008). Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8, 349–361 https://doi.org/10.1038/nri2294 Ricciotti E, FitzGerald GA. (2011) Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 31(5):986-1000. doi: 10.1161/ATVBAHA. Smith FG, Wade AW, Lewis ML, Qi W. (2012) Cyclooxygenase (COX) Inhibitors and the Newborn Kidney. Pharmaceuticals (Basel) 5(11):1160-76. doi: 10.3390/ph5111160. Murdoch JR, Lloyd CM. (2010) Chronic inflammation and asthma. Mutat Res. 690(1-2):24-39. doi: 10.1016/j.mrfmmm.2009.09.005. Farzam, K., Sabir, S. & O'Rourke, M.C. Antihistamines https://www.ncbi.nlm.nih.gov/books/NBK538188/

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