Biochemistry Chanting by Dr. Paras PDF

BIOCHEMISTRY CHANTING BY DR.PARAS  CARBOHYDRATE METABOLISM PATHWAY SITE RATE LIMITING ENC. GLYCOLYSIS/EMBDEN LY TO SOL PFF1- > PHOSPHO- MAYERHOF...

BIOCHEMISTRY CHANTING BY DR.PARAS  CARBOHYDRATE METABOLISM PATHWAY SITE RATE LIMITING ENC. GLYCOLYSIS/EMBDEN LY TO SOL PFF1- > PHOSPHO- MAYERHOFF PATHWAY [EMP] ↑ FRUCTOKINASE - - KREB CYCLE/ MITOCHONDRIAL ISOCITRATE TCA CYCLC3 / MATRIX DELYDROGENASE CITRIC ACID CYCLE GLUCONEOGENESIS LIVERY KIDNEY FRUCTOSE 1 , 6 - BISPHOSPHATASE CY TOSOL& MITROCHONDRIA 2 LYCOGENESIS LIVER & SYSLETAL GLYCOGEN SYNTHASE MUSCLE (CYTOSOL) 2 LYCOGENOLYSIS LIVERA SKELSTAL GLYCOGEN PROSPUORYLASE MUSCLE (CYTOSOL) ump sunt/ LIVER & SKELETAL GGPD > - GLUCOSE- PENTOSE PROSPUATE MUSCLE (CYTOSOL) 6-PHOSPHATE PATHWAY DEHYDROGENASE  PROTEIN METABOLISM PATHWAY SITE I RATE LIMITING ENZYMS UREA CYLE/ LIVER (CYTOSOL CPS - 1 > - CARBAMOYL ORNITHINE CYCLE & MITOCHONDRIA PhoSpUATE SYNTHASE-1 4 TOTAL ATPUSED-3ATP ↳ ACTIVATOR OF CPS-1 - NAG [N-ACETYL-GLUTAMATE] LIPID METABOLISM B-OXIDATION OF MITOCHONDRIA CAT-1- CARNITINE ALYL FATTY ACID TRANSFERASE-I KETOGENESIS MITOCHONDRIA Uma COA SYNTHASE FATTY ALID CYTOSOL ACETYL CoA CARBOXYLASE SYNTHESIS CHOLESTEROL CYTOSOL HMG COA REDUCTASE SYNTHESIS NUCLEOTIDE METABOLISM PURINE SYNTHESIS/PRPP GLUTAMYL AMIDOTRANSFERASE * DISEASE & ENZYME DEFICIENCY A-CARBONYDRATES · VON GIERKE'S DISEASE > DISEASE - IN WHICH BODY CAN'T BREAK DOWN GLYCOGEN > - ENZYME DEFICIENCY > - GLUCOSE-6-PHOSPHATASE · POMPETS DISEASE > - DISEASE IN WHICH BODY CANPT MAKE PROTEIN DUE TO MUTATION IN GAA-GENE & ACID ALPHA-GLUCOSIDASE] ENZYME DEFICIENCY - ACID MALTASE · CORI'S DISEASE > - STRUCTURALLY ABNORMAL GLYLOGEN IS ACCUMULATED THAT IMPAIRYS BODY FUNCTION ENZYME DEFICIENCY > - DEBRANCHING ENZYME · ANDERSON'S DISEASE > - ABNORMAL GLYCOGEN IS PRODUCED AND ACCUMULATED IN BODY ENZYME DEFICIENCY - BRANCHING ENZYME  · Mc ARLDE'S DISEASE ENZYME > - MUSCLE GLYCOGEN PHOSPHORYLASE · HER'S DISEASE ENZYME DEF. > - HEPATIC GLYCOGEN PHOSPHORYLASE · ESSENTIAL FRUCTOSURIA - FRUCTOSE COMING OUT IN URINS ENZYME DEFICIENCY > - FRUCTO KINASE · FRUCTOSE INTOLERANCE > - LACK OF PROTEIN WHICH IS NEEDED To BREADOWN FRUCTOS E ENZYME DEFICIENCY > - ALDOLASE B · GALACTOSSEMIA ENZYME DEFICIENCY > - GALACTOSE-1- PHOSPUATASE URIDYL TRANSFERASS B. PROTEINS · PHENY LKETONURIA > - MOUSY/MUSTY ODOur + NIQ + AMILANN ENZYME - PHENYLALANINE HYDROXYLASE · ALEAPTONURIA BLACK > - URINE DISEASE ENZYME - HOMOGENTISATE OXIDASE CIF-BLUISN BLAKISH DISCOLORATION OF EAR4 SCLERA · MAPLE SYRUP URINE DISEAS S - BURNT SUGAR ODOUR ENZYMES BRANCHED CHAIN KETO ACID DENYDROGENASE/ DECARBOXY LASE AA-AVOIDED - ISOLSUCINE , LSUCING , VALINS C LIPID STORAGE DISEASE. · NIEMANN PICK DISEASE > BODY FAILS TO - METABOLISE LIPID & CHOLESTEROL & THEY 92T ACCUMULATED IN CELLS ENZYME- SPHINGOMYELINASE · GAUCHER'S DISEASE ENZYME > - B-GLUCOCEREBROSIDASE  > - GLOBOlD CELL · KRABBE'S DISEASE > - DEFECT IN GALAC GENE LEAD To DEMYELINATION > - ENZYME-B-GALACTO CEREBROSIDASS · FABRY'S DISEASE > - ENZYME-X-GALACTO CEREBROSIDASE INTRACELLULAR ACCUMULATION OF INCLUSION BODIES WITH A MYELIN 1143 APP. · TAY SACH'S DISEASE -NERVE IN THE BRAIN ARE DESTROYED > - ENZYME-HEXOS AMINIDASE - A · SAND HOFF'S DISEASE > - ENZYME-HEXOS AMINIDAS2-A & B D. NUCLEOTID'S · LESH NYHAN SYNDROME YE-NAIL& LIP BITING > - ENZYME-HGPRT  ↑ * AMINO ACID SPECIAL PRODUCT 1. TYROSINE T , TY , CATECHOLAMING MELANIN , 2. TRYPTOPHAN Vit B3 SEROTONIN MELATONIN , ,. 3 HISTIDINE HISTAMINE 4. ARGININE NITRIC OXIDE & * INHIBITOR 1. FLOURIDE ENOLASE. 2 BARBITURATE AND ROTENONE COMPLEX-I. 3 MALONATE COMPLEX-2 ANTIMYCIN-A , BAL COMPLEX 3 " - CO CNe H2S COMPLEX Y - · , 6 OLGOMYCIN COMPLEX - 3 * CLASSIFICATION OF AMINO ACIDS 1. ALIPUATIC AMINO ACID-G-VALI GLYCNE , VALINE , ALANINE , LEUCINE IsoLEUCINE ,. HYDROXYL GROUP 2 CONTAINING AMINO ACID-S T. SERINE TUREONINE ,. 3 SULPUUR CONTAINING AMINO ACID-M C. METHONINE CYSTEINE , 4. ACIDI AMINO ACID-AA-GG ASPARTIC ACID ASPARAGINE GLUTAMIC ACID , , , GLUTAMINE OXALO ACETATE - ASPARTIC ASPARGINE A4D. BASIC 5 AMINO ACID-HAL MISTIDINE , ARGININE , LYSINE. AROMATIC 6 AMINO ACID-PTT PUENYLALANING , TYROSING TRYPTOPHAN ,. ESSENTIAL 7 AMINO ACID-TV TILL 8P. M TRYPTOPHAN 9 VALINE , TUREONINE , ISOLEUCINE , LEUCINE LYSINE , PHENYLALANINE METHIONING · , 8. SEMI ESSENTIAL AMINO ACID-HA HISTIDINE - ARGININE. 9 KETOGENIC AMINO ACID-LL LEUCINE Ly SING , 10. GLUCOGENIC AND KETOGENIC AMINO ACID-PITT PHENYLALANINE , ISOLEUCINE TRYPTOPHAN , TYROSING , 11. 21st AMINO ACID SELENO CYSTEINE 12 22nd AMINO ACID PYRROLY SINE * MISCELLANEOUS 1. UNCOUPLERS-2 , 4-DNP , ASPIRIN. 2 LIPOPROTEINS WITH HIGHEST CHOLESTEROL-LDL. 3 LIPOPROTEIN WITH HIGHEST TRIGLYCERIDE-CHYLOMICRON U NATURE. OF ENZYME-APOENZYME + COENZYME = HOLOENZYME. 3 COMPETITIVE INNIBITION-Vmax - SAME km 1 - - 6 NON COMPETITIVE INHIBITION-UMAX - t km-SAME -. PROTEIN 7 FOLDING & UNFOLDING. IS DONE BY - CHAPERONE * COFACTOR'S MINERAL FUNCTION COBALT CONSTITUENT VITAMIN B12 Chromium POTENTIATE THE ACTION OF INSULIN FLOURIDE CONSTITUENT OF BONE & TEETH IODINE THYROID NORMONE SYNTHESIS MOLYBDENUM COFACTOR FOR YANTHING OXDASE SELENIUM COFACTOR FOR ELUTATHIONE PEROXIDASE & DELODINASE ZINC C-CARBONIC ANHYDRASE A- ALCOHOL DENYDROGENASS A-ALKALINE PHOSPHATASE L-LACTATE DEHYDROGENASE C I MANGANESE - CARBOXY LASE A-ARLINASE K- KINASE E - ENOLASE * VITAMINS > - FAT SOLUBLE-A D E ,K , , > - WATER SOLUBLE-B4C 1. VITAMIN A > - ACTIVE FORM - RETINOLRX-ACNE > DEFICIENCY - - BITOT SPOT ON CONJUNCTIVA 2. VITAMIND > - ACTIVE FORM OF DS-1 , 25-DIUYDROXY- De > - DEFICIENCY > CHILDREN - RICKETS Y ADULTS > - OSTEOMALACIA 3. VITAMIN E > - ACTIVE FORM - TOCHOPHEROL > - FUNCTION - ANTI-OXIDANT > - DEFICIENCY - HEMOLYTIC ANEMIA CELLULAR DAMAGE 4 VITAMIN K. KI-PUYLLOQUINONE K2- MENA QUINONE K3-MENADIONE DEFICIENCY-BLEEDING DISORDER. VIT 5 BI- THIAMINE DEFICIENCY-WERNICKE'S-KORSKOFFES SYNDROME BERI BERI (MUSCLE WASTING-SYMMETRIC] - OPUTUALMOPLAGIA [OCCULAR MUSCLE WEAKNESS] - 6. VIT B2-RIBOFLAVIN DEFICIENCY - CHEILOSIS - INFLAMMATION Of LP's & SCALING AT THE CORNER 7 VITB3- NIACIN. DEFICIENCY - PELLAGRA DIARRUEA > DERMATITIS > DEMENTIA. 8 VITBS-PANTOTHENIC ACID DEFICIENCY-BURNING FEET DISEASE BCZ OF ADRENAL INSUFFICIENCY 9 VIT B6-PYRIDOXINE DEFICIENCY - SIDEROBLASTIC ANEMIA HYPERIRRITABILITY 10 VITB7- BIOTIN. DEFICIENCY-HAIRLOSS 11 VITAMIN. B9-FOLI ACID DEFICIENCY - MEGALOBLASTIC ANEMIA - NEURAL TUBE DEFECT 12. VIT B12-COBALAMIN DEFICIENCY - MEGALOBLASTIC ANEMIA - SUB ACUTE COMBINED DEGENRATION OF SPINAL CORD 14 Vitamin C-SCURVY Poor Wound HEAUNG 15 Vitamin D-RICKET'S OSTEOMLACIA 16 ZINC DEFICIENCY - DELAYED UEALING WOUND ↓ IMMUNITY ACRODERMATITIS ENTEROPATHICA ↳ DERMATITI LO PECIA PIARRUOSA. LINICAL C BlocnEm * COLLAGEN DEFECT ↳ TYPE I > - OSTEOGENESIS IMPERFECTA ↳ TYPEZ > - CHONDRO-DYSPLASIA ↳ TYPE3 - ELHER DONALDS SYNDROMS R TYPE 4- ALPORT SYNDROME ↳ HEMATUREA ↳ SNUL ↳ ANTERIOR LENTICONUS > - GOOD PASTURE SYNDROM & TIOLOGY - ImmoNE SYSTEM MALING As. WHICH IS ATTACHING COLLAGEN In LUNGAS AND KIDNEY - COLLAGEN AA PRESENT IN COLLAGEN-GLYCINS PROLENE CYSTENE * ↓ vit C ↓ ↓ HYDROXYLATION ↓ FAUITY COLLAGEN ↓ SCURVY * DIETRY FIBER WATER SOLUBLE WATER INSOLUBLE VEIN CELLULOSE i ECTIN um HEMICELLULOSE LIGNN ↳ Neither Mor Digested FERMENYSD.