NA Chemistry PDF
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Uploaded by AmbitiousCornett
Kasr Al-Ainy Faculty of Medicine, Cairo University
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Summary
This document provides notes on NA Chemistry, focusing on topics such as transcription, nitrogenous bases, nucleosides, and nucleotides. It covers major and minor components, and their roles in energy transduction, signaling, and enzyme function.
Full Transcript
# NA Chemistry - Transcription ## Nitrogenous Bases - Purines - **Major**: adenine & guanine - **Minor**: hypoxanthine, xanthine, methylguanine, dietary purines - Pyrimidines - **Major**: cytosine, uracil, thymine - **Minor**: methylcytosine, dihydrouracil ## Nucleosides and Nuc...
# NA Chemistry - Transcription ## Nitrogenous Bases - Purines - **Major**: adenine & guanine - **Minor**: hypoxanthine, xanthine, methylguanine, dietary purines - Pyrimidines - **Major**: cytosine, uracil, thymine - **Minor**: methylcytosine, dihydrouracil ## Nucleosides and Nucleotides - Free: building blocks of DNA & RNA - Function 1: - Energy Transduction - ATP - Source of energy - High energy bonds - cAMP - Function 2: - Signaling Second Messengers - Receptor -> G protein -> adenyl cyclase -> cAMP -> protein ATP - Function 3: - Activated Precursors - Active methionine (SAM) - Phosphoadenosine phosphokinase - COP-choline, ethanolamine, diacylglycerol, uridine diphosphate - Function 4: - Enzymes Components - Nicotinamide Adenine Dinucleotide - Nicotinamide Adenine Dinucleotide Phosphate - Flavin Mono Nucleotide - Flavin Adenine Dinucleotide - Coenzyme A ## Diuretics & CNS Stimulators - Hypoxanthine - uric acid -excl product of purine catabolism - Kanthine - Methylguanine - Caffeine - theophylline - theobromine
