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47 REMEMBER! · Hepatitis (Hepatitis B Antigens & Antibodies) Hep will help you remember...

47 REMEMBER! · Hepatitis (Hepatitis B Antigens & Antibodies) Hep will help you remember the order of Hepatitis B antigens & antibodies! Picture Hep with a shovel trying to clig to the center of the earth. 2) Next, he goes 4) As Hep backs through the out be fills the earth (HBeAg) hole with earth (Anti-HBe) 3) Fipally hv 5)... and, finally 1) First, Hep starts at the surface 1_ rn&ch¢-S tli.e ,, reaches the (HBsAg) ,por~ ,'! -- smi"ace (An,ti-f!Bf).-, (Anti-HBs) Acute Hepatitis B Diagnostic Profile Incubation Acute Infection. Early Recovery Recove Duration (A,., _ (2 ,_,i.,.a moolhs) (3-6 moolhs) 6-13weeks) 1 c; 0 :; l:; C..,..._..J.... anti-HBs \ti 0.s,.... , _ _ _ 5 0 anti HBe, ~ :; 'ii a: Time - - - - - - - - - - - - - - - - - - - - - - - source:CDC Autoimmune Diseases ·';Dis~,,; Associated with MULTIPLE SCLEROSIS (MS) 'Olil{ocliinaiJgG B~ds in 1. Autoantibodies to myelin sheath of. Spinal Fluid· nerves or myelin basic protein 2. Laboratory findings a. Oligoclonal IgG bands in CSF but not in serum (indicates CNS production) b. Usually IgG --Auto.immune Diseases 48 Specificity of Autoantibodies DISEASE AUTOANTIBODY DIRECTED AGAINST: Grave's Disease Receptors for Thyroid Stimulating Hormone (TSH) Goodpasture's Disease Basement Membrane (kidney, lungs) Hashimoto's Thyroiditis Thyroglobulin Multiple Sclerosis Myelin Sheath of Nerves or Myelin Basic Protein Myasthenia Gravis Acetylcholine Receptors at Neuromuscular Junctions Rheumatoid Arthritis lgG (Fe) - 19s anti-lgM autoantibody known as Rheumatoid Factor Sjogren's Syndrome Salivary Duct / Tear Duct 5. Antibodies lead to continual produ ction Impaired Immune Function of thyroid hor mones , T3 & T4 DISEASE DYSFUNCTION 6. T hyroid glands appear enlarged with Chronic Granul omatous lneffecc i ~·e Ph agoc ytos i s Disease diffuse goiter I Chediak-Higashi Syndrome Impaired Neutro ph il 7. Symptoms: weight loss, anxiety £'unction Ii ,II. i l ?f.r 11l ·f~ HASIMO TO'S THYROIDITIS DiGeorge's Syndrome T Cell Deficiency ( Absence of Thymus) 1. Results in hypothyroidism (inadequate lut1. I J: 1, { 'fl£" '.~:.f: -;!:. !./11 production of thyroid hormone) Human Immunodeficiency ! T-Helper Cell.,. Virus (HIV) ! Th /Ts Ratio 2. Autoan tibodies pr oduced against ! T Cell Proliferat ion thyroglob ulin and thyroid cell ,: ,. ,:,:...,.. I Wiskott-Aldrich Syndrome Partial Combined components Immunodeficiency JI ,:: 3. Elevated TSH Severe Combined Complete o r Marked lmmunodeficiei!'lcy Disease Defici e ncy of T and B 4. Elevated thyroid antibodies (SCIO) Lymphocytes a. Thyroid perioxid.ase antibody (TPOAh or anti-TPO) Autoimmune Thyroid Diseases b. Thyroglobulin antibody (TgAh or anti-Tg); may also be present in GRAYES DISEASE thyroid cancer 1. Results in hyperthyroidism 5. Symptoms: weight gain , leth argy, 2. Autoantil)od.ies are directed. against intolerance to col d thyroid stimulating hormone receptors (TSH-R) on thyroid cells 3. LowTSH 4. Elevated thyroid antibodies Antibodies aBBociated with a. Thyroid periox.idase antibody T.byroiD.d Diseases ( TPOAb or anti-TPO) b. Thyroid stimulating hormone receptor antibody ( TRAb or TSHR CBDcers and Associated Ah).IJ'u.mor Marleen c. Thyroid stimulating immunoglobulin (TS])