_26211_246311-L1 Introduction to Pharmaceutical Analysis-I.pdf

Course Code – BP102T Introduction to Pharmaceutical Analysis-I Vision and Mission Vision To generate competent pharmacy professionals to fulfil the needs of pharmacy education, research and industry with the goal to serve society. Mission 1. Develop socially responsible graduates with excellent tec...

Course Code – BP102T Introduction to Pharmaceutical Analysis-I Vision and Mission Vision To generate competent pharmacy professionals to fulfil the needs of pharmacy education, research and industry with the goal to serve society. Mission 1. Develop socially responsible graduates with excellent technical skills. 2. Stimulate the quest for excellence in research among students. 3. Utilization of Himalayan flora for drug discovery and development. Program Educational Objectives (PEOs) of B-Pharm PEO1: Shall be able to utilise their scientific and technical skills for drug and dosage forms development and meet the requirements of academia-industry and research. PEO2: Shall be able to utilise their professional skills in the practice of Pharmacy as Hospital, Clinical or Community Pharmacists. PEO3: Shall follow principles of professional ethics, display effective communication skills and should be able to work as a team with fellow Pharmacists and other healthcare professionals for the benefit of society. PEO4: Should strive to pursue higher education and participate in continuous education programs and other related professional activities in order to keep abreast with the latest developments in the field. Topics to be covered today 1. Introduction to Pharmaceutical Analysis-I Introduction Unit-I: Introduction of Pharmaceutical Analysis 1. Pharmaceutical analysis- Definition and scope i) Different techniques of analysis ii) Methods of expressing concentration iii) Primary and secondary standards. iv) Preparation and standardization of various molar and normal solutions- Oxalic acid, sodium hydroxide, hydrochloric acid, sodium thiosulphate, sulphuric acid, potassium permanganate and ceric ammonium sulphate 2. Errors: Sources of errors, types of errors, methods of minimizing errors, accuracy, precision and significant figures. Introduction Unit-II: Titration 1. Acid base titration: Theories of acid base indicators, classification of acid base titrations and theory involved in titrations of strong, weak, and very weak acids and bases, neutralization curves. 2. Non aqueous titration: Solvents, acidimetry and alkalimetry titration and estimation of Sodium benzoate and Ephedrine HCl. Introduction Unit-III: Titration 1. Precipitation titrations: Mohr’s method, Volhard’s, Modified Volhard’s, Fajans method, estimation of sodium chloride. 2. Complexometric titration: Classification, metal ion indicators, masking and demasking reagents, estimation of Magnesium sulphate, and calcium gluconate. 3. Gravimetry: Principle and steps involved in gravimetric analysis. Purity of the precipitate: co-precipitation and post precipitation, Estimation of barium sulphate. Introduction Unit-IV: Redox titrations (a) Concepts of oxidation and reduction (b) Types of redox titrations (Principles and applications) (Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry, Titration with potassium iodate) Introduction Unit-V: Electrochemical methods of analysis 1. Conductometry- Introduction, Conductivity cell, Conductometric titrations, applications. 2. Potentiometry - Electrochemical cell, construction and working of reference (Standard hydrogen, silver chloride electrode and calomel electrode) and indicator electrodes (metal electrodes and glass electrode), methods to determine end point of potentiometric titration and applications. 3. Polarography - Principle, Ilkovic equation, construction and working of dropping mercury electrode and rotating platinum electrode, applications References 1. Ashutosh Kar, Pharmaceutical Analysis, Volume I, Second edition, CBS Publisher & Distributor PVT. Ltd. New Delhi. 2. Chatwal G.R. and Anand S.K. Instrumental methods of chemical Analysis. 5th Edition (2009), Himalayan Publishing House. 3. Leslie G. Chatten, Pharmaceutical Chemistry theory and Application, CBS Publisher & Distributors Pvt. Ltd., Volume 1. 4. Bahl A. Bahl B.S. and Tuli G.D. Essential of Physical Chemistry.(2008) S. Chand & Compnany Ltd., 7361, Ram Nagar, New Delhi Reference Books: 5. Vogel’s. J Mendham, RC Denney. A Textbook of Quantitative chemical Analysis Pearson Education Pte. Ltd. (Latest Edition). 6. Skoog, West and Holler. Analytical Chemistry (Latest Edition). 7. Indian Pharmacopoeia. The Indian Pharmacopeia Commission, Central Indian Pharmacopeia, Laboratory, Govt. of India. Ministry of Health and Family Welfare, Ghaziabad (Latest Edition). 8. A.H. Beckett & J.B. Stenlake's, Practical Pharmaceutical Chemistry Vol I & II, Stahlone Press of University of London (Latest Edition). Question Which one is not an Electrochemical methods of analysis 1. Conductometry 2. Gravimetry 3. Potentiometry 4. Polarography Question Which one is not an Electrochemical methods of analysis 1. Conductometry 2. Gravimetry 3. Potentiometry 4. Polarography Thank you Dr. Navneet Kumar Upadhyay School of Pharmaceutical Sciences Shoolini University Village Bajhol, Solan (H.P) +91 9805581371 [email protected]