2009PHM EOM Infection Revision Quiz PDF

03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz NAME : 2009PHM EOM Infection Revision Quiz 50 Questions CLASS : DATE : 1. How does the HIV drug nevirapine act? A Blocking the 30S ribosomal subunit to halt protein synthesis B It integrates into the viral chromosomal DNA C Becoming ph...

03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz NAME : 2009PHM EOM Infection Revision Quiz 50 Questions CLASS : DATE : 1. How does the HIV drug nevirapine act? A Blocking the 30S ribosomal subunit to halt protein synthesis B It integrates into the viral chromosomal DNA C Becoming phosphorylated three times D Being incorporated into viral DNA, causing chain termination E Changing the conformation of reverse transcriptase 2. Which drug target does sulfadoxine inhibit in protozoa? A The ribosomal 50S subunit B Dihydrofolate reductase C Haem polymerase D Dihydropteroate synthetase E β-lactamase 3. What tuberculosis drug affects arabinogalactan? A Rifampicin B Propylthiouracil C Ethambutol D Isoniazid E Pyrazinamide https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 1/11 03/10/2023, 10:35 4. 2009PHM EOM Infection Revision Quiz SuperQ: How is the mechanism of action of foscarnet different from ganciclovir? It A treats the Herpes simplex virus and B not cytomegalovirus binds to interferon receptors on human immune cells C blocks DNA polymerase directly without being phosphorylated acts on RNA polymerase D 5. Which of the following HIV drugs changes the conformation of HIV reverse transcriptase? A Darunavir B Enfuvirtide C Zidovudine D Maraviroc E Nevirapine 6. After a Gram stain, what features of the cells should you talk about? A that rod = coccus B C 2 possible shapes; 2 possible colours D E only talk about the shapes 7. Which of the following is a DNA virus? A Herpes B HIV C Covid-19 D Influenza 8. Which of the following (multiple answers possible) are caused by herpes varicella zoster? A herpetic eye infections B shingles C acute chickenpox D genital herpes E orolabial herpes https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 1 possible shape or colour only talk about their colours 2/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 9. Which of the following formulations treats shingles and genital herpes? A topical aciclovir B foscarnet C high-dose aciclovir D IV aciclovir E oral famciclovir 10. Which enzyme is the drug target for aciclovir? A human DNA polymerase B viral DNA polymerase C viral thymidine kinase D viral adenosine kinase E viral protease 11. Which of the following drugs (multiple answers possible) need to be phosphorylated 3 times? A tenofovir B foscarnet C zidovudine D ganciclovir E aciclovir 12. Which of the following is the influenza drug target for zanamivir? A thymdine kinase B M2 ion channel C neuraminidase D RNA polymerase E DNA polymerase 13. WHat does the HIV drug raltegravir prevent? A Incorporation of viral DNA into host chromosomal DNA C Fusion of the HIV to the immune cell membrane https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 B D Extension of the growing DNA chain Conversion of inert proteins into structural and functional ones 3/11 03/10/2023, 10:35 14. 2009PHM EOM Infection Revision Quiz SuperQ: Which of the following hepatitis C direct-acting antivirals inhibits the viral RNA polymerase? A NS12A inhibitors B ribavirin C NS3/4A inhibitors D NS5A inhibitors E NS5B inhibitors 15. Which of the following is a NUCLEOTIDE reverse transcriptase inhibitor drug? A zidovudine B lamivudine C tenofovir D emtricitibine E didanosine 16. In treating HIV, which THREE outcomes occur when a NRTI drug becomes phosphorylated? A It chops up polyproteins into small proteins B It causes viral DNA chain termination C It competes with the host 5'triphosphorylated base E It inhibits HIV reverse transcriptase 17. Select any of the following that are FALSE about NNRTIs such as nevirapine, D It changes the conformation of reverse transcriptase efavirenz and etravirine A C E They require phosphorylation to the active form They are prodrugs B D They bind to the active site of HIV reverse transcriptase They change the shape of HIV reverse transcriptase enzyme They are analogues of DNA/RNA bases https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 4/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 18. HIV protease inhibitors block viral A polymerisation B maturation C resistance D selectivity E condensation 19. Which HIV drug binds to the chemokine co-receptor 5 (CCR5) located on the surface of some immune cells? A didanosine B darunavir C amoxicillin D maraviroc E enfuvirtide 20. SuperQ: Which type of agar should you perform disc diffusion assays on? A Mannitol Salt Agar B Chocolate Agar C Mueller-Hinton agar D Horse Blood Agar E MacConkey agar 21. Which of the following is NOT a visual outcome that you could determine from a Gram stain? A lactose fermenting cells B dark blue cells C pink cells D bacilli (rod-shaped) cells E cocci cells 22. What is the drug target of flucytosine? A cytosine polymerase B cytosine deaminase C cytosine reductase D haem polymerase E cytosine permease https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 5/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 23. Which antibiotic is now more often used to treat Staphylococcus aureus due to increasing levels of bacterial resistance? A gentamicin B moxifloxacin C flucloxacillin D streptomycin E amoxicillin 24. Which of the following is a HIV fusion protein inhibitor? A raltegravir B maraviroc C etravirine D enfuvirtide 25. SuperQ: Which of these is the current first-line initial HIV therapy? A Two N(t)RTIs + an NNRTI + PI B C Two N(t)RTIs + integrase strand inhibitor (INSTI) D E One N(t)RTI + an NNRTI or PI 26. Two N(t)RTIs + an NNRTI or PI One NNRTI + two PIs Which broad-spectrum TB drug inhibits the Mycobacterium RNA polymerase enzyme? A Pyrazinamide B Rifampicin C Isoniazid D Ethambutol https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 6/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 27. What is the Mycobacterium drug target for pyrazinamide? A fatty acid synthase B fatty acid desaturase C pyrazinoic acid D pyrazinamidase 28. SuperQ: What does the "P" stand for in the PICO approach when appraising evidence and making a question in Evidence Based Practice? A Profiles B Performance C Projection/plot D Probability E Patient/population 29. Which of the following activated drugs cause incorrect synthesis of fungal DNA? A dTMP B 5-FdUmp C DRcUMP D metronidazole radicals E dUMP epoxidase 30. Which penicillin drug may be fatal if administered intravenously? A oxacillin B benzylpenicillin C ticarcillin D procaine penicillin https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 7/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 31. Bacterial meningitis is most commonly caused by which pathogen? A Proteus mirabilis B Pseudomonas aeruginosa C Herpes complex D Streptococcus pneumoniae E Staphylococcus aureus 32. Which generation of cephalosporins are able to easily penetrate the blood brain barrier? A Third B Second C Fourth D First 33. Which penicillin is an anti-Staphylococcus drug? A piperacillin B dicloxacillin C ampicillin D phenoxymethylpenicillin 34. A C What is the major means by which bacterial resistance has arisen to vancomycin? The red neck syndrome pathway Mutation of D-Ala-D-Ala pentapeptide B D Development of bacterial efflux pumps Extended spectrum β-lactamases 35. Which protein synthesis inhibitor can bind the bacterial 30S subunit AND create membrane holes? A tetracyclines B chloramphenicol C gentamicin D erythromycin https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 8/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 36. Phototoxicity and disruption of growth of bone and teeth is an ADE of which antibiotic? A clarithromycin B doxycycline C streptomycin D quinupristin/dalfopristin 37. Consider this chemical structure. What is the name of this drug? A Griseofulvin B Oseltamivir C Nystatin D Flucytosine E Caspofungin 38. SuperQ: Which of the following is a urinary tract antiseptic? A clindamycin B linezolid C metronidazole D nitrofurantoin 39. Which antimalarial drug(s) produces free radicals that inhibit malarial proteins (multiple answers possible)? A artesunate B artemether C mefloquine D primaquine E atovaquone with proguanil 40. What is the drug target for albendazole in a nematode worm? A voltage-gated Cl- channels B α receptors C β-tubulin D cholinergic receptors https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 9/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 41. Which drug makes the worm parasite permeable to Ca2+ and also induces the host immune reponse? A ivermectin B albendazole C pyrantel pamoate D praziquantel 42. To which class does this chemical structure belong? A Echinocandins B Nucleosides C Allylamines D Polyenes E Azoles 43. A patient's Archilles tendon has snapped. Which medications below are the most likely cause? A mupirocin B roxithromycin C streptogramins D ciprofloxacin 44. Which bacterial species grow on Mannitol Salt Agar (MSA)? A Streptomyces B E. coli C Staphylococcus D Streptococcus 45. Which type of haemolysis occurs on blood agar when bacterial colonies are green? A none B epsilon C partial D full https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 10/11 03/10/2023, 10:35 2009PHM EOM Infection Revision Quiz 46. SuperQ: Why does S. aureus turn MSA plates to a yellow colour? A non-mannitol fermentation B mannitol fermentation C mannitol reducing D lactose fermentation 47. Which type of bacteria grow on MacConkey plates? A Gram-positive cocci B Staphylococcus only C All colonic bacteria D Gram-negative bacilli 48. What colour are bacterial colonies when they ferment lactose on MacConkey plates? A yellow B white C pink D clear 49. What does this Gram stain tell you about the bacteria (multiple answers possible)? A Gram positive cocci B It's a pure culture C It's a mixed culture D Gram negative cocci E Gram positive bacilli 50. SuperQ: Using this Table, which antibiotic is INEFFECTIVE against Acinetobacter species? A gentamicin B amikacin C imipenem D tobramycin E ertapenem https://quizizz.com/print/quiz/64c0f894c02ef700079e66f2 11/11