Pharmaceutical Organic Chemistry Laboratory Experiments PDF

# المحاضرة الاولى Lab 1 Date: Hyoscine bettyl bromide: * **Organic group:** Monocyclic Alicyclic * **M.O.A:** Anticholinergic (Ach) * **Uses:** * Antispasmodic - For Irritable bowel Syndrome * Motion Sickness * **Physical properties:** 1. White crystalline Powder 2. Freely Soluble in water of Methylene 3. Sparingly Soluble in anhydrous ethanol. Result: - Violet color will form. # المحاضرة الثانية Lab 2 Identifacation of Adrenaline. * **Organic class:** Catecholamine / Arylakylaminol * **M.O.A:** Stimulates α and β -adrenylk receptor * **Uses:** 1. In anaphylactic shock. 2. Acute attack of asthma 3. With local anaesthesia. - Cardiac Arrest * **Physical properties:** 1. White or greyish crystalline powder 2. Freely Soluble in water 3. Slightly Soluble in ethanol 96% Result: - Orangish red with Iz # المحاضرة الثالثة Lab 3 Date: Identification Methyl dope * **Organic class:** Phenethylamine / phenyl-ethylamine - Chote cholethylamina. * **M.O.A:** α2-adrenergic receptors. * **Uses:** As anti-hypertensive agent. * **Physical properties:** 1. Colorless or almost Colorless crystals - or white to yellowish fine powder 2. slightly Soluble in water and alcohol 3. Practically insoluble in chloroform - >10,000ml * **Observation:** dark blue color. # المحاضرة الرابعة Lab 4 Identifacation Orphandrine Citrate * **Orgnic class:** Diphenylmethane. * **M.O.A:** Antichdinergic. * **Uses:** 1. Muscle relaxant 2. In parkinson’s as adjuvant * **Physical properties:** 1. White Crystalline pouder 2. Sparingly Soluble in water. Result: - Orangish red Hasy drop by drop # المحاضرة الخامسة Lab 5 Date: Identification of Sodium thyroxin. * **Orgnic class:** Aryl propianic acide * **Uses:** In hypothyroidism * **M.O.A:** Acts as endogenous thyroid H * **Physical properties:** 1. Crystalline Powder 2. slightly Soluble in water 3. In Soluble in benzene. * **Observation:** Yellow Color will change to orange. # المحاضرة السادسة Lab 6/ Tetracycline * **Organic class:** Polycyclic compound * **M.O.A:** Bacteriosiatic * **Uses:** In many infections as acne and URTI. * **Physical properties:** 1. yellow crystalline. 2. sparingly Soluble in water 3. Slightly Soluble in ethanol * **Observation:** - Chang :color Riddish videt: to yellow - Present of - H2504 conc - Diw # المحاضرة السابعة Lab 7 Date: / Chloroquine phosphate * **Organic class:** 4-aminoquino.line. * **M.O.A:** Inhibits heme polymerase activaty * **Uses:** 1. Ottt of acute attack of malaria. 2. Ht of exraintestinal amebiasis * **Physical properties:** 1. white or slightly yellow crystalline Powder 2. Freely Soluble in water. 3. Soluble in Chloroform of ether * **Observation:** formational of white P.PT # المحاضرة الثامنة Lab 8 Indomethacine * **Organic class:** Benzoylindaline Theterocyclic cpd * **M.O.A:** Cox inhibitor * **Uses:** 1. Analgesic 2. Antipyretic 3. Anti-inflammatory * **Physical properties:** 1. Palle yellow crystalline powder 2. Soluble in acetone, ethanol, ether - of chloro-form 3. Insoluble in water, Result: / Bright yellow color. # المحاضرة التاسعة Lab 9 Date: / Ascorbic Acid * **Chemical Class:** Dihydro Lavan * **M..A:** Cofactor * **Uses:** - Treatment of deficiency of vit.c - Delayed wound of - Scurvy - bone healing - Urine acidification - Antioxidant * **Physical Properties:** 1. white or pate yellow. 2. Freely-Soluble in water. * **Observation:** - Blue color becomes light or disappear. # الكيمياء العضوية الصيدلانية ## Pharmaceutical Organic Chemistry اضافة الكلوروفورم أثناء استخلاص القديس الاستخدام الدورة الليل 1. **Addition of Chloroform during extraction of Hyoscine butyl bromide.** - To separate and dissolve hyoscine butyl bromide **From the Components in the tablet.**   2. **Heating after addition of chloroform to hyoscine butyl bromide.** - **To remove Chloroform and get hyoscine butylbromide only for more purification.**     3. **Addition of acetone during extraction of hyoscine butyl bromide.** - **To purify H. B.B From the remaining chloroform**   4. **Addition of HNO3 during identification of H.B.B.?** - **To Convert hyoscine butyl Bromide From Salt Form to organic Form**   5. **Addition of chloroform during extraction of orphenadrine Citrate** - **To separate and dissolve orphenadrine citrate From the components in the tablet.**    6. **Washing the tablet containing methyldopa by Chloroform.** - **To get ride of Coat & Facilitate powderin.**   7. **Addition of conc. HCl tablet containing thyroxin** - **To Convert thyroxine From Salt to organic Form.**  # Follow Up الالالالا 8. **Addition of ethanol during extraction of thyroxin.** - **To separate and dissolve thyroxin From the Components in tablet.**   9. **Addition of ethanol during extraction of tetracycline.** - **To Separate and dissolve tetracycline From the Components in capsule.**    10. **Powdering of tablet before any extraction.** - **To get Fine powder →↑ Surface area For extraction.**    11. **Addition of Dow during extraction of Chloroquine phosphate table.** - **To dissolve chloroquine phosphate and other Water Soluble Components as Mg+2 and Catz**     12. **Adolition of Naoh during extraction of chloroquine phosphate.** - **1. To convert chloroquine phosphate to its Free base Form.**  - **2. To remove phosphate ion.**  - **3. To remove Mg+2 and Catz Salts which are precipitated into Ca(OH)2 and Mg(OH)2**    13. **Addition of diethyl ether during extraction of Chloroquine phosphat.** - **To dissolve chloroquine Free base**   # Follow up 14. **Appearance of white P.P.T after addition of BaCl2** - **Dut to Formation of Baz (PO4)2 P.P.T.** - **- Ваз (PO4)2 ↓** - **+ 2004** - **The upper Layer of the mixture inside the separating Funnel is diethyl ether.** - **Always the Upper Layer is for Liquid with Low density (DEE has Low density).** 15. **Appearance of orangish red color after addition of H2504 to orphenadrine citrate.** - **Due to Chemical reaction that produces Colored Complex (nitroso-orphenadrine)**   16. **Appearance of yellow color after heating of NaNO3 with thyroxin.** - **Sodium nitrite Can react with amino group in thyroxin leading to the Formation of nitroso- cpal which responsible For the color.**   17. **Appearance of orange red color after addition of NH4OH to the Salt of thyroxin.** - **Because the reaction can involve the interaction of NH4OH with specific Functional groups in thyroxin molecule (CH- Cool) ie carbon atom that binds to carboxy and amino group.**   18. **Apperrance of bright yellow color during testing indomethacin by Naoli.** - **Due to Formation of Na. indomethacin as Follow.** ![chemical equation](image.png) 19. **Disappearance of blue color during heating the mixture Containing ascorbic acid with methylene blue.** - **Due to a redox reaction where ascorbic acid acts as a reducing agent, which reduces_methylene blue (blue dye) to its Colorless Form (Leucomethylene blue).** - **Heating here will increase the reaction rate Leading to Faster reduction and_quicker disappearance..**

Pharmaceutical Organic Chemistry Laboratory Experiments PDF

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