Microb-Manager Tech Sheet PDF

SELF EMULSIFYING DELIVERY SYSTEM MICROB-MANAGER ® THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRA...

SELF EMULSIFYING DELIVERY SYSTEM MICROB-MANAGER ® THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITIONERS”). THIS INFORMATION IS INTENDED FOR PRACTITIONERS TO USE AS A BASIS FOR DETERMINING WHETHER TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. ALL RECOMMENDATIONS REGARDING PROTOCOLS, DOSING, PRESCRIBING AND/OR USAGE INSTRUCTIONS SHOULD BE TAILORED TO THE INDIVIDUAL NEEDS OF THE PATIENT CONSIDERING THEIR MEDICAL HISTORY AND CONCOMITANT THERAPIES. THIS INFORMATION IS NOT INTENDED FOR USE BY CONSUMERS. Microb-Manager® is a premier immune formula designed to support healthy microbial balance inside the body. Artemisinin, berberine, broad spectrum hemp extract, propolis, and andrographis help support a balanced and resilient microbial terrain, while curcuminoids and boswellia extract help maintain a healthy inflammatory response to microbes. Milk thistle and quercetin aid healthy liver function and balance mast cell activity. EDUCATION BOTANICALS: THE WAY OF THE FUTURE FOR MANAGING MICROBES The invention of pharmaceutical antibiotics in the 20th century has dramatically changed our world. Vast reductions in infectious disease mortality and morbidity have come at the cost of bacterial antibiotic resistance, now considered a “global crisis.”1 In the United States, two million people acquire antibiotic-resistant infections each year; this number continues to rise.2 The dwindling efficacy of pharmaceutical antibiotics has led to a resurgence of scientific interest in traditional medicinal plants for supporting the body’s antimicrobial defenses.3 Unlike antibiotics, plant extracts utilize multiple mechanisms to selectively target pathogenic microbes, reducing the risk of antibiotic resistance while promoting a healthy microbial balance.3 BOTANICALS CONFER ANTIMICROBIAL ACTIVITY Artemisia annua, an intensely bitter and aromatic botanical, has been used for thousands of years in Traditional Chinese Medicine for the treatment of chills and fever of an infectious origin.4 Its primary active ingredient, artemisinin, has potent antimalarial activity and is the basis for artesunate, a synthetic antimalarial drug. However, artemisinin also has formidable antimicrobial activity against a variety of other pathogens, including periodontal microbes and Staphylococcus aureus.5 It is also a candidate drug against Borrelia burgdorferi, the cause of Lyme disease, and has antioxidant and anti-inflammatory properties.6,7,8 Artemisinin’s ability to block the cellular multidrug efflux system in bacteria, involved in the development of antibiotic resistance, makes it an especially valuable botanical in the modern-day clinician’s antimicrobial toolkit.7 Berberine, the bitter yellow alkaloid found in the roots and bark of various Berberis species, also has potent antimicrobial activity against pathogenic microbes, not to mention its long history of use for inflammatory conditions.9,10 Cinnamon essential oil is also antimicrobial with activity against Borrelia burgdorferi, H. pylori, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans.11,12 The hemp-based phytocannabinoid CBD is well-known for its analgesic and anti-inflammatory properties. CBD is also a potent antimicrobial, inhibiting the growth of Staphylococcus aureus and Streptococcus pneumoniae with a potency similar to that of vancomycin and daptomycin.13 The antimicrobial and anti-inflammatory activity of CBD, make hemp extract an attractive option for treating infections while also minimizing the harmful effects of pathogen-induced inflammation on the body. BOTANICALS MODULATE CYTOKINE RESPONSE Botanicals with dual antimicrobial and anti-inflammatory properties help limit microbial survival while tempering the body’s response to physical irritations.13 Curcuminoids, including curcumin and turmeric essential oils, are found in the brilliant yellow rhizome of Curcuma longa. They possess a wide range of pharmacological activities, including antimicrobial and anti-inflammatory effects. Curcumin inhibits the growth of Staphylococcus aureus, E. coli, Salmonella, and Candida while simultaneously decreasing pro-inflammatory cytokines.14,15,16 It also potentiates the antimicrobial activity of artemisinin.17 Turmeric essential oils enhance curcumin bioavailability and possess unique anti-inflammatory properties.18 Boswellia, the fragrant resin from the Boswellia serrata tree, has been used for millennia in Indian Ayurvedic medicine for the treatment of inflammation. It too possesses an impressive array of antimicrobial activities, inhibiting the growth of Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Klebsiella pneumonia, Pseudomonas aeruginosa, and Proteus vulgaris.19 It also inhibits oral pathogens and biofilm formation, while modulating inflammatory pathways triggered by infection.20,21,22,23 Interestingly, a combination of curcumin and Boswellia extract is more potent than either compound alone for supporting a healthy cytokine response.24 MILK THISTLE AND QUERCETIN OFFER LIVER AND MAST CELL SUPPORT Microbial pathogens have damaging effects on the liver, impairing the liver’s natural detoxification capacities.25 Milk thistle is profoundly hepatoprotective, supporting liver function while also balancing the immune system and systemic inflammatory responses.26 The polyphenol quercetin, found in edible plants ranging from green tea to apples, helps stabilize mast cells modulating the body’s inflammatory response to immune stressors. Natural mast cell stabilization may help the most sensitive patients better tolerate medications and supplements, improving adherence to protocols.27,28 BUILD A RESILIENT INTERNAL TERRAIN French microbiologist Louis Pasteur, famous for his germ theory of disease, is purported to have stated on his deathbed that “the terrain is everything.” His simple but profound statement alluded to the importance of a robust internal environment, including a healthy immune system, as the body’s best defense. Andrographis and propolis are rich sources of immunomodulatory compounds that support a healthy internal terrain, fortifying the body against microbial stressors. Andrographolide, a primary constituent of Andrographis, has potent immune- stimulating, anti-microbial, anti-inflammatory properties.29,30,31 Propolis, a resinous mixture produced by honeybees, has immunomodulatory, antibacterial, antiviral, and antifungal effects.32,33,34 SEDS DELIVERY TECHNOLOGY Self-emulsifying delivery systems (SEDS) represent a new frontier in nutraceutical delivery systems. SEDS are formulations of oils and surfactants that quickly dissolve in the stomach upon contact with gastric juices, creating emulsified nanoparticles that quickly diffuse across cellular membranes and enter the bloodstream.30 SEDS improve the oral absorption of lipophilic (“fat-loving”) compounds, including fat-soluble vitamins and phytonutrients, which are notorious for their poor bioavailability. SEDS delivery systems can help overcome significant bioavailability challenges, allowing powerful natural compounds to exert systemic benefits. TS230002 References available at quicksilverscientific.com/microbmanagerreferences/ Rev. 00 WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT, BREAST-FEEDING, OR PLANNING TO BECOME PREGNANT. KEEP OUT OF REACH OF CHILDREN. Consult a healthcare professional before use if you have any medical condition or are taking any other supplements or medications. Do not exceed recommended dosage. See www.quicksilverscientific.com for additional safety information. This information is for the use of licensed healthcare practitioners only and is intended to use as a basis for ® determining whether or not to recommend these products to their patients. This medical and scientific information is not for use by consumers.