Regulation Of Gene Expression 2022-2023 PDF

NFNF1613 REGULATION OF GENE EXPRESSION Dr. Nor Syafinaz Yaakob Faculty of Pharmacy, UKM [email protected]  LECTURE OBJECTIVES Understand activation and suppression of gene expression Understand gene regulation at different points/lev...

NFNF1613 REGULATION OF GENE EXPRESSION Dr. Nor Syafinaz Yaakob Faculty of Pharmacy, UKM [email protected]  LECTURE OBJECTIVES Understand activation and suppression of gene expression Understand gene regulation at different points/level Understand genetic changes that are associated with cellular aging  DEFINITION https://www.genome.gov/genetics-glossary/Gene-Expression ON or OFF?  REGULATION BY TRANSCRIPTION INITIATION  REGULATION BY TRANSCRIPTION TERMINATION PREMATURE TRANSCRIPTION TERMINATION (PTT) IN YEAST Porrua, O., Libri, D. Transcription termination and the control of the transcriptome: why, where and how to stop. Nat Rev Mol Cell Biol 16, 190–202 (2015). https://doi.org/10.1038/nrm3943 REGULATION BY mRNA SPLICING REGULATION BY TRANSLATION  REGULATION BY ACCESS TO DNA https://www.cusabio.com/c- 20826.html Histone Modification Patterns and Their Responses to Environment March 2014 Current Environmental Health Reports 1(1):11-21 DOI: 10.1007/s40572-013-0008-2 Hongzheng DaiHongzheng DaiZhibin WangZhibin Wang  REFERENCES Lippincott’s Illustrated Reviews: Biochemistry (6th Ed) GENE EXPRESSION IN AGING  AGING - DEFINITION “progressive physiological changes in an organism that lead to senescence, or a decline of biological functions and of the organism’s ability to adapt to metabolic stress. Aging takes place in a cell, an organ, or the total organism with the passage of time.” (Britannica) “At the biological level, ageing results from the impact of the accumulation of a wide variety of molecular and cellular damage over time.” (WHO) Aging can be defined as the time-related deterioration of the physiological functions necessary for survival and fertility. The characteristics of aging……………affect all the individuals of a species. (Developmental Biology, 6th Ed) HALLMARKS OF AGING THANK YOU ANY QUESTIONS?