Pharm GERD and PUD Quizizz PDF

Worksheets Name Pharm GERD and PUD Class Total questions: 60 Worksheet time: 30mins...

Worksheets Name Pharm GERD and PUD Class Total questions: 60 Worksheet time: 30mins Date Instructor name: Mr. hkvxdgsnsg apple_user 1. Which of the following is the most common cause of GERD? a) Relaxation of the lower esophageal sphincter b) Hypercalcemia c) H. pylori infection d) Obesity 2. What is the primary therapeutic action of proton pump inhibitors in GERD? a) Binding H2 receptors in gastric parietal cells b) Inhibiting acid secretion via H+/K+ ATPase c) Coating gastric ulcers d) Neutralizing stomach acid 3. Which of the following medications can worsen GERD symptoms? a) Antacids b) Calcium channel blockers c) Proton pump inhibitors d) Beta-blockers 4. When should a proton pump inhibitor be taken for optimal effectiveness? a) With antacids b) At bedtime c) Immediately after eating d) 30-60 minutes before meals 5. What is the main goal of drug therapy for GERD? a) Alleviate symptoms b) All of the above c) Promote mucosal healing d) Prevent Barrett’s esophagus https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 1 of 12 :  6. Which condition is characterized by mucosal injury due to the imbalance of protective and harmful gastric factors? a) GERD b) Barrett’s esophagus c) Celiac disease d) Peptic ulcer disease 7. What is the first-line treatment for H. pylori-associated PUD? a) Bismuth quadruple therapy b) PPI monotherapy c) High-dose antacids d) Clarithromycin triple therapy 8. Which antibiotic is commonly part of both triple and quadruple therapies for H. pylori? a) Ciprofloxacin b) Doxycycline c) Vancomycin d) Amoxicillin 9. For NSAID-induced PUD, which of the following actions is recommended for prevention? a) Reducing NSAID dosage b) All of the above c) Adding a PPI d) Switching to COX-2 selective NSAIDs 10. What is the primary goal of drug therapy for PUD? a) Resolve symptoms b) Reduce acid secretion c) Promote epithelial healing d) All of the above 11. What is the mechanism of action for amoxicillin? a) Inhibits proton pumps b) Neutralizes gastric acid c) Disrupts bacterial DNA d) Inhibits bacterial cell wall synthesis 12. Which of the following antibiotics is associated with a disulfiram-like reaction when combined with alcohol? a) Clarithromycin b) Tetracycline c) Amoxicillin d) Metronidazole https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 2 of 12 :  13. Which class does clarithromycin belong to? a) Aminoglycosides b) Macrolides c) Fluoroquinolones d) Tetracyclines 14. What adverse effect is most commonly associated with long-term proton pump inhibitor use? a) C. difficile infections b) Rebound hypersecretion c) Constipation d) Alopecia 15. Which of the following is a common complication of untreated GERD? a) Gastric carcinoma b) Peptic stricture c) Zollinger-Ellison syndrome d) Celiac disease 16. Which of the following lifestyle changes is most recommended for patients with nocturnal GERD symptoms? a) Avoid lying down 1-2 hours after eating b) Take antacids before bedtime c) Eat smaller meals d) Avoid spicy foods 17. What is the first step in managing GERD symptoms in a newly diagnosed patient? a) Start a proton pump inhibitor b) Perform endoscopy c) Lifestyle modifications d) Initiate H2 receptor antagonist 18. Which PUD-related condition is associated with severe gastric acid hypersecretion and gastrin-producing tumors? a) Stress ulcer b) H. pylori infection c) Zollinger-Ellison syndrome d) NSAID-induced ulcers https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 3 of 12 :  19. Which drug combination is most appropriate for clarithromycin triple therapy? a) PPI + clarithromycin + amoxicillin b) Antacid + sucralfate + amoxicillin c) PPI + tetracycline + metronidazole d) H2RA + metronidazole + bismuth 20. What is the duration of therapy for both clarithromycin triple therapy and bismuth quadruple therapy for H. pylori? a) 14 days b) 10 days c) 7 days d) 21 days 21. Which of the following adverse effects is most associated with tetracycline use? a) Hypokalemia b) Tooth discoloration c) Constipation d) Black stool 22. What mechanism of action does bismuth subsalicylate provide in PUD treatment? a) Forms a protective barrier over ulcers b) Enhances gastric emptying c) Neutralizes stomach acid d) Reduces acid production 23. Why should tetracycline be avoided in children under 8 years of age? a) Risk of CNS toxicity b) Risk of liver failure c) Risk of tooth discoloration d) Risk of teratogenicity 24. What is the primary difference between proton pump inhibitors (PPIs) and H2 receptor antagonists? a) PPIs neutralize acid b) H2 blockers reduce acid secretion less effectively c) H2 blockers inhibit acid-neutralizing bacteria d) PPIs reduce stomach pH https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 4 of 12 :  25. What adverse effect is associated with long-term omeprazole use? a) Tooth discoloration b) Hyperkalemia c) Hypocalcemia d) Vitamin B12 deficiency 26. What is the black box warning associated with metoclopramide? a) Acute renal failure b) Hepatotoxicity c) C. difficile infection d) Tardive dyskinesia 27. Which of the following is a contraindication for misoprostol use? a) GERD b) Lactation c) Pregnancy d) H. pylori treatment 28. What is a common interaction between cimetidine and other medications? a) Enhances antibiotic action b) Reduces warfarin efficacy c) Inhibits CYP450 enzymes d) Reduces PPI effectiveness 29. Why should aluminum hydroxide be used cautiously in patients with renal impairment? a) Risk of hypophosphatemia b) Risk of hyperkalemia c) Risk of hyperphosphatemia d) Risk of hepatotoxicity 30. What is a key difference between calcium carbonate and magnesium hydroxide antacids? a) Calcium carbonate reduces iron absorption b) Calcium carbonate causes diarrhea c) Magnesium hydroxide causes constipation d) Magnesium hydroxide causes diarrhea https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 5 of 12 :  31. What is the mechanism of action of proton pump inhibitors (PPIs)? a) Enhances gastric emptying b) Inhibits H+/K+ ATPase in gastric parietal cells c) Neutralizes stomach acid d) Binds to H2 receptors 32. Which drug class does metronidazole belong to? a) Macrolide b) Nitroimidazole c) Fluoroquinolone d) Aminoglycoside 33. What is the primary indication for sucralfate? a) Peptic ulcer disease (PUD) b) H. pylori infection c) Stress ulcers d) GERD 34. Which of the following is a contraindication for misoprostol use? a) GERD b) Lactation c) Pregnancy d) H. pylori treatment 35. What is the mechanism of action of amoxicillin? a) Inhibits protein synthesis b) Inhibits bacterial cell wall synthesis c) Neutralizes gastric acid d) Disrupts bacterial DNA synthesis 36. Which of the following is an indication for bismuth subsalicylate? a) Gastroparesis b) Zollinger-Ellison syndrome c) GERD d) Diarrhea https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 6 of 12 :  37. What class of drugs does cimetidine belong to? a) Antacids b) Mucosal protectants c) H2 receptor antagonists d) Proton pump inhibitors 38. What is the mechanism of action of clarithromycin? a) Disrupts bacterial cell wall synthesis b) Neutralizes gastric acid c) Inhibits DNA gyrase d) Inhibits protein synthesis by binding to 50S ribosomal subunit 39. Which drug is indicated for the prevention of NSAID-induced gastric ulcers? a) Misoprostol b) Amoxicillin c) Cimetidine d) Sucralfate 40. What is a common contraindication for tetracycline use? a) Lactation b) Pregnancy and children under 8 c) GERD d) Peptic ulcer disease 41. What is the class of drugs to which omeprazole belongs? a) Proton pump inhibitors b) Mucosal protectants c) H2 receptor antagonists d) Antacids 42. Which of the following drugs works by forming a protective coating over gastric ulcers? a) Misoprostol b) Bismuth subsalicylate c) Metoclopramide d) Sucralfate https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 7 of 12 :  43. What is the mechanism of action of aluminum hydroxide? a) Inhibits protein synthesis b) Neutralizes gastric acid c) Inhibits H+/K+ ATPase d) Enhances gastric motility 44. Which of the following is an indication for metoclopramide? a) GERD in pregnancy b) Peptic ulcer disease c) H. pylori eradication d) Gastroparesis 45. What is a contraindication for the use of magnesium hydroxide antacids? a) Lactation b) Stress ulcers c) GERD d) Severe renal impairment 46. What is the mechanism of action of amoxicillin? a) Neutralizes gastric acid b) Inhibits bacterial cell wall synthesis c) Inhibits protein synthesis by binding to 30S d) Disrupts bacterial DNA synthesis ribosomal subunit 47. Which class does amoxicillin belong to? a) Cephalosporins b) Tetracyclines c) Macrolides d) Penicillins https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 8 of 12 :  48. Which of the following is a contraindication for amoxicillin use? a) Renal impairment b) Pregnancy c) Hypersensitivity to penicillins d) GERD 49. What is the most common adverse effect of amoxicillin? a) QT prolongation b) Photosensitivity c) Nephrotoxicity d) Diarrhea 50. What is the mechanism of action of metronidazole? a) Neutralizes stomach acid b) Inhibits bacterial cell wall synthesis c) Inhibits protein synthesis by binding to 50S d) Disrupts bacterial DNA synthesis ribosomal subunit 51. Which condition is an indication for metronidazole? a) H. pylori infection b) Zollinger-Ellison syndrome c) Gram-positive bacterial infections d) Viral gastroenteritis 52. Which of the following is a contraindication for metronidazole? a) Alcohol use within 48 hours b) Use in children c) Renal failure d) GERD https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 9 of 12 :  53. What is a unique adverse effect of metronidazole? a) Disulfiram-like reaction with alcohol b) Hepatotoxicity c) Photosensitivity d) Black stool 54. What is the mechanism of action of clarithromycin? a) Inhibits bacterial cell wall synthesis b) Neutralizes gastric acid c) Inhibits DNA gyrase d) Inhibits protein synthesis by binding to 50S ribosomal subunit 55. Which class does clarithromycin belong to? a) Aminoglycosides b) Tetracyclines c) Fluoroquinolones d) Macrolides 56. Which of the following is a contraindication for clarithromycin? a) GERD b) QT-prolonging conditions c) Peptic ulcer disease d) Alcohol consumption 57. What is the mechanism of action of tetracycline? a) Inhibits bacterial cell wall synthesis b) Neutralizes gastric acid c) Inhibits protein synthesis by binding to 30S d) Disrupts bacterial DNA synthesis ribosomal subunit 58. What is the primary indication for tetracycline in PUD treatment? a) Stress ulcers b) GERD c) H. pylori infection d) NSAID-induced ulcers https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 10 of 12 :  59. Which of the following is a contraindication for tetracycline use? a) Zollinger-Ellison syndrome b) Pregnancy and children under 8 c) Renal impairment d) GERD 60. What is a common adverse effect of tetracycline? a) Hepatotoxicity b) Neutropenia c) QT prolongation d) Tooth discoloration in children Answer Keys 1. a) Relaxation of the lower 2. b) Inhibiting acid secretion via 3. b) Calcium channel blockers esophageal sphincter H+/K+ ATPase 4. d) 30-60 minutes before meals 5. b) All of the above 6. d) Peptic ulcer disease 7. d) Clarithromycin triple therapy 8. d) Amoxicillin 9. b) All of the above 10. d) All of the above 11. d) Inhibits bacterial cell wall 12. d) Metronidazole synthesis 13. b) Macrolides 14. a) C. difficile infections 15. b) Peptic stricture 16. a) Avoid lying down 1-2 hours 17. c) Lifestyle modifications 18. c) Zollinger-Ellison syndrome after eating 19. a) PPI + clarithromycin + 20. a) 14 days 21. b) Tooth discoloration amoxicillin 22. a) Forms a protective barrier 23. c) Risk of tooth discoloration 24. b) H2 blockers reduce acid over ulcers secretion less effectively 25. d) Vitamin B12 deficiency 26. d) Tardive dyskinesia 27. c) Pregnancy 28. c) Inhibits CYP450 enzymes 29. a) Risk of hypophosphatemia 30. d) Magnesium hydroxide causes diarrhea 31. b) Inhibits H+/K+ ATPase in 32. b) Nitroimidazole 33. a) Peptic ulcer disease (PUD) https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 11 of 12 :  gastric parietal cells 34. c) Pregnancy 35. b) Inhibits bacterial cell wall 36. d) Diarrhea synthesis https://quizizz.com/print/quiz/673c0c1846e61c5d1d38828f 11/22/24, 1 56 AM Page 12 of 12 :