Module 9 Unit D Infestations 2024 PDF

Module 9 Unit D Infestations Class Drug Indications MOA Safety considerations BBW Notes examples contraindications Generic/Tra...

Module 9 Unit D Infestations Class Drug Indications MOA Safety considerations BBW Notes examples contraindications Generic/Tra D2D de QT Insecticidal Permethrin Head lice Permethrin, a SE/Adverse effects -None noted Pregnancy/l agents 1% (Nix) Pediculosis pubis pyrethroid, is - contact dermatitis, actation: Scabies active against a asthma Safe broad range of exacerbation, mild pests including and transient **Note: lice, ticks, fleas, burning, stinging, mites, and other Non- and pruritis. arthropods. It ovicidal acts on the nerve Contraindications: therapies for cell membrane to - Avoid in patients pediculosis disrupt the with should be sodium channel chrysanthemum applied current by which allergy. twice, seven the polarization to 10 days of the membrane D2D interactions: apart, is regulated. - Not specifically Delayed notated. But always repolarization do a medication and paralysis of reconciliation the pests are the consequences of QT prolongation/Risk of this disturbance. TdP Permethrin is rapidly - None metabolized by  ester hydrolysis to inactive metabolites which are excreted primarily in the urine Pyrethrins 0.3%/ piperonyl butoxide 4% (Rid) Neurotoxic to Malathion the lice 0.5% lotion (Ovide) Scabicides Gammaxene Treatment of scabies Lindane Lotion SE/Adverse effects WARNINGS -Pregnancy/ and (Lindane) (infestations of Sarcoptes USP, 1%, is an - CNS stimulant Lindane Lotion should only be lactation: pediculicide scabei ) only in patients who: ectoparasiticide when absorbed used in patients who cannot Do not use s 1. cannot tolerate other and ovicide systemically, tolerate or have failed first-line approved therapies, or effective resulting in treatment with safer 2. have failed treatment against Sarcoptes convulsions and medications for the treatment with other approved scabiei (scabies). death. of scabies. therapies. Lindane exerts its Lindane Lotion should be parasiticidal Contraindications: -Neurologic Toxicity used in the context of an action by being - Premature infants Seizures and deaths have been overall scabies management directly absorbed because their skin reported following Lindane program that includes: into the parasites may be more Lotion use with repeat or Microscopic and their ova permeable than that prolonged application, but also evaluation of skin in rare cases following a single  scrapings to confirm of full term infants application used according to the diagnosis. and their liver directions. Lindane Lotion Evaluation and enzymes may not be should be used with caution for treatment of sexual sufficiently infants, children, the elderly, contacts developed to and individuals with other skin simultaneously. metabolize Lindane. conditions (e.g., atopic Sexual contacts dermatitis, psoriasis) and in - For patients with should be prescribed those who weigh < 110 lbs (50 crusted (Norwegian) Lindane Lotion only kg) as they may be at risk of if they either have scabies and other serious neurotoxicity. failed to respond to skin conditions adequate doses of (e.g., atopic -Contraindications other approved dermatitis, psoriasis) Lindane Lotion is therapies or are that may increase contraindicated in premature intolerant of other systemic absorption infants and individuals with approved therapies. of the drug. known uncontrolled seizure Washing of all - For patients with disorders. recently worn known clothing, underwear, uncontrolled seizure -Proper Use pajamas, used sheets, Instruct patients on the proper disorders and for pillowcases, and use of Lindane Lotion, the individuals with a towels in very hot amount to apply, how long to water or dry-cleaned. known sensitivity to leave it on, and avoiding the product or any retreatment. Inform patients of its components that itching occurs after the successful killing of scabies and Caution: is not necessarily an indication - Avoid contact with for retreatment with Lindane Lotion eyes D2D interactions - Antipsychotics  - Antidepressants - Theophylline - Cyclosporine, mycophenolate mofetil, tacrolimus capsules - Penicillins, imipenem, quinolone antibiotics - Chloroquine sulfate, pyrimethamine - Isoniazid - Meperidine - Radiographic contrast agents - Centrally active anticholinesterases - Methocarbamol QT prolongation/Risk of TdP - None Pyrethrins Permethrin Treatment of infestation Permethrin, a SE/Adverse effects: - None noted - 5% (Elimite) with Sarcoptesscabiei (scabies) pyrethroid, is - Burning and Pregnancy/l active against a stinging followed actation: broad range of application with Use with pests including Permethrin Cream caution lice, ticks, fleas, 5% , pruritus,  mites, and other erythema, arthropods. It numbness, tingling, acts on the nerve rash, headache, cell membrane to fever, dizziness, disrupt the abdominal pain, sodium channel diarrhea and nausea current by which and/or vomiting. the polarization of the membrane Contraindications: is regulated. - Known Delayed hypersensitivity repolarization and paralysis of Caution: the pests are the - For temporary use consequences of only. this disturbance. D2D interactions: Permethrin is - A rapidly metabolized by QT prolongation/Risk of ester hydrolysis TdP: to inactive - None metabolites which are excreted primarily in the urine Resources: Textbook Lexicomp LactMed CredibleMeds