Lecture 1: Introduction To Intermediary Metabolism And Bioenergetics PDF
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University of Guyana
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This document is a lecture on introduction to intermediary metabolism and bioenergetics, part of a Biochemistry II course at the University of Guyana. It covers topics such as the course introduction, objectives, assessment methods, and lecture schedules. The lecture also introduces biomolecules, chemical reactions, and concepts of free energy, thermodynamics, ATP, and redox potential.
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UNIVERSITY OF GUYANA FACULTY OF NATURAL SCIENCES DEPARTMENT OF BIOLOGY BIO 3110 BIOCHEMISTRY II – Intermediary Metabolism LECTURE 1: Intermediary Metabolism and the Principles of Bioenergetics Course Introdu...
UNIVERSITY OF GUYANA FACULTY OF NATURAL SCIENCES DEPARTMENT OF BIOLOGY BIO 3110 BIOCHEMISTRY II – Intermediary Metabolism LECTURE 1: Intermediary Metabolism and the Principles of Bioenergetics Course Introduction and Objectives On successful completion of the course, students should be able to: 1. Explain clearly what is intermediary metabolism and the concept of metabolic pathways. 2. Differentiate accurately between anabolism and catabolism. 3. Explain why metabolic pathways are not considered closed systems. 4. Deduce the existence of common metabolic pathways in cells using relevant examples. 5. Discuss how several diseases arise from the defects in the metabolic pathways. Methods of Assessment In course tests: 3 @ 8% each [ TOTAL: 24%] – [face – to – face] 1st Test: Week 4 2nd Test: Week 8 3rd Test: Week 12 Written Assignment: 1 [TOTAL: 10%] Laboratory assessments: 16% Final written examination (2 hours): 50% [face–to–face] Students are expected to achieve an overall pass in the written assignments and final written examination. Outline of BIOCHEMISTRY II Lectures Lecture 1: Introduction to Intermediary Metabolism and the Principles of Bioenergetics Lecture 2: Carbohydrates and Glycobiology Lecture 3: Carbohydrate Biosynthesis (Glycolysis and Gluconeogenesis) [Test 1] Lecture 4: The Citric Acid Cycle and Oxidative Phosphorylation Lecture 5: Fatty Acid Catabolism Lecture 6: Lipid Biosynthesis (Protein and Lipid Metabolic Pathways) [Test 2] Lecture 7: Amino Acid Oxidation Lecture 8: Synthesis of amino acids and nucleotides Lecture 9: Cancer Cell Metabolism [Test 3] Lecture 10: Starvation and the Metabolic Limits of Human Performance Outline of BIOCHEMISTRY II Laboratory Exercises Lab 1: The effect of substrate concentration on catalysis Lab 2: The effect of enzyme concentration on enzyme activity Lab 3: The effect of pH on Catalysis Lab 4: The effect of temperature on Catalysis Lab 5: Enzyme Immobilisation Lab 6: The Iodine Test for Starch Lab 7: The Biuret Test for Protein ATTENDANCE TO LECTURES AND LABS FOR BIO3110 IS COMPULSORY Introduction to Bio-molecules Intermediary Metabolism Xenobiotics are foreign chemicals or toxins that may accumulate in the body, usually due to exposure to pollutants and deactivated and/or secreted primary by the liver. The Concept of Bioenergetics The Concept of Free Energy The Principles of Bioenergetics Important State functions for the study of biological systems Relationship between the change in free energy, enthalpy, and entropy Redox Potential Types of Bioenergetic Reactions Adenosine Triphosphate (ATP) The Structure of ATP END OF LECTURE 1
