Drugs Used in Mood Disorders Part 7.docx

\#\#\# \*\*Slide 55: NMDA Receptor Antagonists\*\* 1\. \*\*What is the primary mechanism of action of NMDA receptor antagonists like ketamine in depression treatment?\*\* \- A. Serotonin reuptake inhibition \- B. NMDA receptor antagonism \- C. Dopamine receptor blockade \- D. GABA receptor acti...

\#\#\# \*\*Slide 55: NMDA Receptor Antagonists\*\* 1\. \*\*What is the primary mechanism of action of NMDA receptor antagonists like ketamine in depression treatment?\*\* \- A. Serotonin reuptake inhibition \- B. NMDA receptor antagonism \- C. Dopamine receptor blockade \- D. GABA receptor activation \*\*Answer:\*\* B. NMDA receptor antagonism 2\. \*\*Esketamine (Spravato) is indicated for which of the following conditions?\*\* \- A. Generalized anxiety disorder \- B. Treatment-resistant depression and acute suicidal ideation \- C. Obsessive-compulsive disorder \- D. Bipolar disorder \*\*Answer:\*\* B. Treatment-resistant depression and acute suicidal ideation 3\. \*\*What is a major concern regarding the use of ketamine in depression treatment?\*\* \- A. Weight gain \- B. Risk of dissociative symptoms and abuse potential \- C. Increased risk of seizures \- D. Hyperglycemia \*\*Answer:\*\* B. Risk of dissociative symptoms and abuse potential \-\-- \#\#\# \*\*Slide 56: How to Choose an Antidepressant\*\* 1\. \*\*Which of the following antidepressants is least likely to cause sexual side effects?\*\* \- A. Bupropion \- B. Fluoxetine \- C. Paroxetine \- D. Citalopram \*\*Answer:\*\* A. Bupropion 2\. \*\*What is a key consideration when choosing an antidepressant for a patient?\*\* \- A. Only the cost of the drug \- B. Indication, cost, availability, adverse effects, drug interactions, and history of response \- C. The patient\'s weight \- D. The patient\'s age \*\*Answer:\*\* B. Indication, cost, availability, adverse effects, drug interactions, and history of response 3\. \*\*Which antidepressant class is most commonly prescribed for major depressive disorder (MDD) and anxiety disorders?\*\* \- A. Tricyclic antidepressants (TCAs) \- B. Monoamine oxidase inhibitors (MAOIs) \- C. Selective serotonin reuptake inhibitors (SSRIs) \- D. NMDA receptor antagonists \*\*Answer:\*\* C. Selective serotonin reuptake inhibitors (SSRIs) \-\-- \#\#\# \*\*Slide 57: Clinical Indications for Antidepressants\*\* 1\. \*\*What is the goal of acute treatment with antidepressants in patients with depression?\*\* \- A. Reduce the number of depressive symptoms by half \- B. Achieve full remission of depressive symptoms \- C. Manage symptoms to a tolerable level \- D. Maintain the patient on therapy for life \*\*Answer:\*\* B. Achieve full remission of depressive symptoms 2\. \*\*How long should a trial of antidepressant therapy last before determining efficacy?\*\* \- A. 1-2 weeks \- B. 8-12 weeks \- C. 6 months \- D. 4 weeks \*\*Answer:\*\* B. 8-12 weeks 3\. \*\*In patients who have experienced two or more serious episodes of major depressive disorder (MDD) in the last 5 years, what is recommended?\*\* \- A. Short-term therapy for 3 months \- B. Long-term antidepressant therapy \- C. Discontinue medication and focus on psychotherapy \- D. Use only psychotherapy \*\*Answer:\*\* B. Long-term antidepressant therapy \-\-- \#\#\# \*\*Slide 58: Antidepressant Side Effects and Discontinuation\*\* 1\. \*\*Which antidepressant class is associated with the highest risk of fatal overdose?\*\* \- A. Selective serotonin reuptake inhibitors (SSRIs) \- B. Serotonin-norepinephrine reuptake inhibitors (SNRIs) \- C. Tricyclic antidepressants (TCAs) \- D. NMDA receptor antagonists \*\*Answer:\*\* C. Tricyclic antidepressants (TCAs) 2\. \*\*What is a common symptom of antidepressant discontinuation syndrome?\*\* \- A. Euphoria \- B. Dizziness and paresthesias \- C. Seizures \- D. Constipation \*\*Answer:\*\* B. Dizziness and paresthesias 3\. \*\*Which antidepressants are most likely to cause severe withdrawal symptoms if stopped abruptly?\*\* \- A. Long half-life SSRIs (e.g., fluoxetine) \- B. Short half-life SSRIs (e.g., paroxetine, sertraline) \- C. NMDA receptor antagonists \- D. MAOIs \*\*Answer:\*\* B. Short half-life SSRIs (e.g., paroxetine, sertraline) \-\-- \#\#\# \*\*Slide 59: Antidepressant Drug Interactions\*\* 1\. \*\*What effect do paroxetine and fluoxetine have on the cytochrome P450 (CYP) enzyme system?\*\* \- A. They are potent CYP2D6 inhibitors \- B. They induce CYP2D6 activity \- C. They inhibit CYP3A4 \- D. They have no effect on the CYP enzyme system \*\*Answer:\*\* A. They are potent CYP2D6 inhibitors 2\. \*\*Which antidepressants are relatively free from significant drug interactions?\*\* \- A. Paroxetine and fluoxetine \- B. Citalopram and sertraline \- C. Venlafaxine and duloxetine \- D. Bupropion and mirtazapine \*\*Answer:\*\* B. Citalopram and sertraline 3\. \*\*Which of the following drugs is contraindicated with SSRIs due to the risk of serotonin syndrome?\*\* \- A. Beta-blockers \- B. MAOIs \- C. Antihistamines \- D. NSAIDs \*\*Answer:\*\* B. MAOIs \-\-- \#\#\# \*\*Slide 60: Serotonin Syndrome\*\* 1\. \*\*What is a key sign of serotonin syndrome?\*\* \- A. Hypotension \- B. Hyperthermia and autonomic instability \- C. Bradycardia \- D. Hypoglycemia \*\*Answer:\*\* B. Hyperthermia and autonomic instability 2\. \*\*Which of the following is commonly used to treat serotonin syndrome by blocking serotonin receptors?\*\* \- A. Cyproheptadine \- B. Diazepam \- C. Lorazepam \- D. Fluoxetine \*\*Answer:\*\* A. Cyproheptadine 3\. \*\*Which class of drugs is most commonly associated with serotonin syndrome?\*\* \- A. Antipsychotics \- B. Antidepressants (e.g., SSRIs, SNRIs) \- C. Beta-blockers \- D. Benzodiazepines \*\*Answer:\*\* B. Antidepressants (e.g., SSRIs, SNRIs)