Drugs Used in Mood Disorders Part 3 PDF

\#\#\# \*\*Slide 21: Bupropion (Wellbutrin)\*\* 1\. \*\*What is the primary mechanism of action of bupropion (Wellbutrin)?\*\* \- A. Selective serotonin reuptake inhibitor \- B. Norepinephrine and dopamine reuptake inhibitor \- C. Monoamine oxidase inhibitor \- D. Glutamate antagonist \*\*Answ...

\#\#\# \*\*Slide 21: Bupropion (Wellbutrin)\*\* 1\. \*\*What is the primary mechanism of action of bupropion (Wellbutrin)?\*\* \- A. Selective serotonin reuptake inhibitor \- B. Norepinephrine and dopamine reuptake inhibitor \- C. Monoamine oxidase inhibitor \- D. Glutamate antagonist \*\*Answer:\*\* B. Norepinephrine and dopamine reuptake inhibitor 2\. \*\*Bupropion is contraindicated in patients with which of the following conditions?\*\* \- A. Anxiety disorders \- B. Seizure disorders \- C. Chronic kidney disease \- D. Hypertension \*\*Answer:\*\* B. Seizure disorders 3\. \*\*Which of the following is a benefit of bupropion compared to SSRIs?\*\* \- A. Lower risk of sexual side effects \- B. More sedating effect \- C. Increased serotonin reuptake \- D. Reduced risk of weight loss \*\*Answer:\*\* A. Lower risk of sexual side effects【48:6†source】 \-\-- \#\#\# \*\*Slide 22: New Medication - Dextromethorphan/Bupropion ER (Auvelity)\*\* 1\. \*\*What is the mechanism of action of dextromethorphan in Auvelity?\*\* \- A. NMDA receptor antagonist \- B. Serotonin reuptake inhibitor \- C. Dopamine receptor agonist \- D. GABA agonist \*\*Answer:\*\* A. NMDA receptor antagonist 2\. \*\*Which medication is combined with dextromethorphan in Auvelity to enhance its antidepressant effects?\*\* \- A. Sertraline \- B. Bupropion \- C. Fluoxetine \- D. Mirtazapine \*\*Answer:\*\* B. Bupropion 3\. \*\*What is a significant risk when combining dextromethorphan with serotonergic medications?\*\* \- A. Hypertensive crisis \- B. Hypoglycemia \- C. Serotonin syndrome \- D. Bradycardia \*\*Answer:\*\* C. Serotonin syndrome【48:13†source】 \-\-- \#\#\# \*\*Slide 23: Trazodone (Desyrel)\*\* 1\. \*\*What is the primary mechanism of action of trazodone at low doses?\*\* \- A. NMDA receptor antagonist \- B. Histamine receptor antagonist \- C. Alpha-1 receptor antagonist and 5-HT2A receptor antagonist \- D. Dopamine receptor agonist \*\*Answer:\*\* C. Alpha-1 receptor antagonist and 5-HT2A receptor antagonist 2\. \*\*Trazodone is commonly used at low doses to treat which of the following conditions?\*\* \- A. Anxiety disorders \- B. Hypertension \- C. Insomnia \- D. Bipolar disorder \*\*Answer:\*\* C. Insomnia 3\. \*\*What is a rare but serious side effect of trazodone that requires immediate medical attention?\*\* \- A. Priapism \- B. Serotonin syndrome \- C. Agranulocytosis \- D. Stevens-Johnson syndrome \*\*Answer:\*\* A. Priapism【48:13†source】 \-\-- \#\#\# \*\*Slide 24: Mirtazapine (Remeron)\*\* 1\. \*\*Which receptor is antagonized by mirtazapine to increase norepinephrine and serotonin levels?\*\* \- A. Alpha-2 adrenergic receptor \- B. Beta-adrenergic receptor \- C. Dopamine D2 receptor \- D. NMDA receptor \*\*Answer:\*\* A. Alpha-2 adrenergic receptor 2\. \*\*What is a common side effect of mirtazapine, especially at lower doses?\*\* \- A. Insomnia \- B. Weight gain \- C. Nausea \- D. Hypertension \*\*Answer:\*\* B. Weight gain 3\. \*\*Mirtazapine is less likely to cause which of the following side effects compared to SSRIs?\*\* \- A. Sexual dysfunction \- B. Weight gain \- C. Drowsiness \- D. Dry mouth \*\*Answer:\*\* A. Sexual dysfunction【48:1†source】 \-\-- \#\#\# \*\*Slide 25: NMDA Receptor Antagonists\*\* 1\. \*\*Which of the following NMDA receptor antagonists is approved for treatment-resistant depression?\*\* \- A. Ketamine \- B. Fluoxetine \- C. Lithium \- D. Sertraline \*\*Answer:\*\* A. Ketamine 2\. \*\*What is a common side effect of esketamine (Spravato), an NMDA receptor antagonist?\*\* \- A. Euphoria \- B. Dissociation \- C. Bradycardia \- D. Hypoglycemia \*\*Answer:\*\* B. Dissociation 3\. \*\*NMDA receptor antagonists are thought to work in depression by modulating which neurotransmitter system?\*\* \- A. Serotonin \- B. Glutamate \- C. Dopamine \- D. GABA \*\*Answer:\*\* B. Glutamate【48:13†source】 \-\-- \#\#\# \*\*Slide 26: Monoamine Oxidase Inhibitors (MAOIs)\*\* 1\. \*\*What is the primary mechanism of action of monoamine oxidase inhibitors (MAOIs)?\*\* \- A. Inhibition of serotonin reuptake \- B. Inhibition of the enzyme that breaks down norepinephrine, dopamine, and serotonin \- C. Activation of GABA receptors \- D. Antagonism of NMDA receptors \*\*Answer:\*\* B. Inhibition of the enzyme that breaks down norepinephrine, dopamine, and serotonin 2\. \*\*Which of the following foods should be avoided by patients taking MAOIs?\*\* \- A. Bananas \- B. Cheese \- C. Chicken \- D. Oranges \*\*Answer:\*\* B. Cheese 3\. \*\*Combining MAOIs with SSRIs can result in which life-threatening condition?\*\* \- A. Hypothyroidism \- B. Serotonin syndrome \- C. Renal failure \- D. Hyperkalemia \*\*Answer:\*\* B. Serotonin syndrome【48:5†source】 \-\-- \#\#\# \*\*Slide 27: MAOI Side Effects and Interactions\*\* 1\. \*\*Which of the following is a common side effect of MAOIs?\*\* \- A. Weight loss \- B. Orthostatic hypotension \- C. Hypertension \- D. Hyperglycemia \*\*Answer:\*\* B. Orthostatic hypotension 2\. \*\*MAOIs should not be combined with which of the following medications due to the risk of hypertensive crisis?\*\* \- A. Beta-blockers \- B. SSRIs \- C. Antipsychotics \- D. Antihistamines \*\*Answer:\*\* B. SSRIs 3\. \*\*Which of the following is a serious interaction that can occur when MAOIs are combined with sympathomimetics?\*\* \- A. Bradycardia \- B. Hypothermia \- C. Hypertensive crisis \- D. Hyperthermia \*\*Answer:\*\* C. Hypertensive crisis【48:6†source】 \-\-- \#\#\# \*\*Slide 28: Tricyclic Antidepressants (TCAs)\*\* 1\. \*\*Tricyclic antidepressants (TCAs) block the reuptake of which neurotransmitters?\*\* \- A. Serotonin and dopamine \- B. Serotonin and norepinephrine \- C. Norepinephrine and acetylcholine \- D. GABA and dopamine \*\*Answer:\*\* B. Serotonin and norepinephrine 2\. \*\*Which of the following is a serious side effect of TCA overdose?\*\* \- A. QT prolongation and cardiac arrhythmias \- B. Hyperglycemia \- C. Bradycardia \- D. Hyponatremia \*\*Answer:\*\* A. QT prolongation and cardiac arrhythmias 3\. \*\*Which TCA is most commonly prescribed for obsessive-compulsive disorder (OCD)?\*\* \- A. Amitriptyline \- B. Desipramine \- C. Clomipramine \- D. Imipramine \*\*Answer:\*\* C. Clomipramine【48:9†source】 \-\-- \#\#\# \*\*Slide 29: TCA Side Effects\*\* 1\. \*\*Which of the following side effects is associated with the anticholinergic properties of TCAs?\*\* \- A. Diarrhea \- B. Urinary retention \- C. Bradycardia \- D. Weight loss \*\*Answer:\*\* B. Urinary retention 2\. \*\*What is a common central nervous system (CNS) side effect of TCAs?\*\* \- A. Insomnia \- B. Sedation \- C. Anxiety \- D. Hallucinations \*\*Answer:\*\* B. Sedation 3\. \*\*Which receptor blockade contributes to the fall risk associated with TCAs? \*\* \- A. Alpha-1 adrenergic receptor blockade \- B. Beta-2 adrenergic receptor blockade \- C. NMDA receptor blockade \- D. GABA receptor blockade \*\*Answer:\*\* A. Alpha-1 adrenergic receptor blockade【48:9†source】 \-\-- \#\#\# \*\*Slide 30: TCA Overdose\*\* 1\. \*\*What is the primary cause of death in TCA overdose?\*\* \- A. Respiratory depression \- B. Cardiovascular toxicity (arrhythmias) \- C. Liver failure \- D. Seizures \*\*Answer:\*\* B. Cardiovascular toxicity (arrhythmias) 2\. \*\*Which electrolyte imbalance is commonly associated with TCA overdose?\*\* \- A. Hyperkalemia \- B. Hyponatremia \- C. Hypocalcemia \- D. Hyperphosphatemia \*\*Answer:\*\* B. Hyponatremia 3\. \*\*What treatment is contraindicated in TCA overdose due to its worsening effect on arrhythmias?\*\* \- A. Sodium bicarbonate \- B. Class I antiarrhythmics (e.g., procainamide) \- C. Activated charcoal \- D. Benzodiazepines \*\*Answer:\*\* B. Class I antiarrhythmics (e.g., procainamide)【48:9†source】