Leukemia and Lymphoma PDF
Document Details
Uploaded by RegalElder7207
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences
2024
Chaya Prasad
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Summary
Dr. Prasad presents a detailed overview of leukemia and lymphoma, covering objectives, normal lab values, and various blood cell types. The presentation features diagrams and images.
Full Transcript
LEUKEMIA AND LYMPHOMA CHAYA PRASAD, MD, MBA FINANCIAL DISCLOSURE NONE OBJECTIVE To understand the clinicopathologic features and laboratory diagnosis of 1. Benign Reactive white cell disorders. 2. Infectious scenarios 3. Acute and chronic leukemias 4. Lym...
LEUKEMIA AND LYMPHOMA CHAYA PRASAD, MD, MBA FINANCIAL DISCLOSURE NONE OBJECTIVE To understand the clinicopathologic features and laboratory diagnosis of 1. Benign Reactive white cell disorders. 2. Infectious scenarios 3. Acute and chronic leukemias 4. Lymphoproliferative disorders 5. Chronic Myeloid Leukemia (CML) NORMAL LAB VALUES Leukocyte count 4500-11,000/mm3 Segmented neutrophils 54-62% (0.54-0.62) Bands 3-5% (0.03-0.05) Eosinophils 1-3% (0.01-0.03) Basophils 0-0.75% (0-0.0075) Lymphocytes 25-33% (0.25-0.33) Monocytes 3-7% (0.03-0.07) Leukopenia less than 4.5 K Leukocytosis greater than 11 K Usually affects one cell line. Differentiation of blood cells (hematopoiesis) CFU, Colony forming unit. LIN, lineage-specific markers. Sca-1, stem cell antigen-1 cKit, stem cell factor Usual types of circulating leukocytes Band Eosinophil Platelet Neutrophil Lymphocyte Basophil Monocyte ERYTHROID MATURATION NORMAL BONE MARROW Megakaryocyte Fat Bone marrow smear, maturation of neutrophils Myelocyte Metamyelocyte Promyelocyte Band Erythroid Erythroid neutrophil Myeloblast Left shift Blast Promyelocyte Myelocyte Metamyelocyte Band Mature (PMN) Normal PBS
