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Antimicrobial therapy FOLIC ACID SYNTHESIS AND REDUCTION (DNA methylation) Sulfonamides Sulfamethoxazole Sulfadiazine Trimethoprim MEMBRANE INTEGRITY Daptomycin (gram →) Polymyxins (gram →) CELL WALL SYNTHESIS PEPTIDOGLYCAN SYNTHESIS Glycopeptides Vancomycin Bacitracin PEPTIDOGLYCAN CROSS-LINKING Pe...

Antimicrobial therapy FOLIC ACID SYNTHESIS AND REDUCTION (DNA methylation) Sulfonamides Sulfamethoxazole Sulfadiazine Trimethoprim MEMBRANE INTEGRITY Daptomycin (gram →) Polymyxins (gram →) CELL WALL SYNTHESIS PEPTIDOGLYCAN SYNTHESIS Glycopeptides Vancomycin Bacitracin PEPTIDOGLYCAN CROSS-LINKING Penicillinase-sensitive penicillins Penicillin G, V Ampicillin Amoxicillin Penicillinase-resistant penicillins Oxacillin Nafcillin Dicloxacillin DNA INTEGRITY (via free radicals) Metronidazole PABA DHF maba THF Antipseudomonal Piperacillin DNA BACTERIAL CELL RNA- polymerase Cell membrane Cell wall 3rd-Ceftriaxone, etc 4th-Cefepime 5th-Ceftaroline Carbapenems Imipenem Cephalosporins (I-V) 1st-Cefazolin, etc 2nd-Cefoxitin, etc Monobactams Aztreonam Meropenem Ertapenem 50S 30S mRNA SYNTHESIS (RNA polymerase) Rifampin mRNA Ribosomes 50S 30S DNA gyrase 50S 30S paar Fluoroquinolones Ciprofloxacin Ofloxacin GYRASE Levofloxacin Moxifloxacin 30S SUBUNIT Aminoglycosides Gentamicin Neomycin Amikacin Tobramycin Streptomycin PROTEIN SYNTHESIS 50S SUBUNIT Chloramphenicol Clindamycin Linezolid Macrolides Azithromycin Clarithromycin Erythromycin Streptogramins Quinupristin Dalfopristin Glycylcycline Tigecycline Tetracyclines Tetracycline Doxycycline Minocycline 民