photo.jpg

# Hemophilia - Hemophilia is an inherited disorder in which the child lacks adequate clotting factors. - There are 3 types: - Type A: lack of clotting factor VIII (90% of cases) - Type B: lack of clotting factor IX - Type C: Lack of clotting factor XI (affects both sexes, rarely occurs...

# Hemophilia - Hemophilia is an inherited disorder in which the child lacks adequate clotting factors. - There are 3 types: - Type A: lack of clotting factor VIII (90% of cases) - Type B: lack of clotting factor IX - Type C: Lack of clotting factor XI (affects both sexes, rarely occurs in the US) - Both Type A and B are usually X-linked disorders, affecting only males. - The severity of the disease depends on the amount of clotting factor in the blood. - Babies often show symptoms when more active, crawling or walking, with frequent bruises. - Symptoms include: - Bleeding with severe trauma or stress (mild cases) - Unexplained bruises, bleeding, swelling, joint pain - Spontaneous hemorrhage (severe cases), often in the joints but can be anywhere in the body. - Epistaxis. - Treatment includes: - Desmopressin parenterally or nasally to stimulate production of clotting factor (mild cases) - Infusions of clotting factor from donated blood or recombinant clotting factors (genetically engineered) - Infusions of plasma (Type C) # Von Willebrand Disease - Von Willebrand disease is a group of congenital bleeding disorders (inherited from either parent) - Affecting 1-2% of the population, associated with deficiency or lack of von Willebrand factor (vWF)