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## Cardiology ### Notes: Other causes of heart failure: * Valvular * Congenital * Ischemia related ### Etiology: Genetic (30%): H/o cardiac disease in family (+) | Type of CMP | Inheritance pattern | Protein mutated | |---|---|---| | DCMP | Autosomal dominant | TV (Truncated variant) titin >...

## Cardiology ### Notes: Other causes of heart failure: * Valvular * Congenital * Ischemia related ### Etiology: Genetic (30%): H/o cardiac disease in family (+) | Type of CMP | Inheritance pattern | Protein mutated | |---|---|---| | DCMP | Autosomal dominant | TV (Truncated variant) titin > myosin heavy chain 7> troponin I. | | ARVD | Autosomal recessive | Desmosome | | LV non compaction | x-linked recessive | Tafazzine protein | Variability in presentations between patients d/t variable penetrance and expression. * Peripartum cardiomyopathy (CMP) - Good prognosis * Alcohol-induced CMP - Good prognosis * Drug-induced CMP - Bad prognosis. * Toxin/nutrition induced CMP: Deficiencies of * Thiamine. * Selenium (In sub-Himalayan zone: Keshan's disease). * Carnitine. | | | |---|---| | **Sarcoidosis** | Dilated component > restrictive component. | | **Hemochromatosis** | | | **Autoimmune** | | | **Endocrine** | | * Pheochromocytoma. * Thyroid disease. * Obesity. * **Inflammatory CMP (myocarditis)** | | ### Complications: * Thromboembolism. * Arrhythmias (D/t dilated LV). * Sudden cardiac death (SCD). * Decompensation (↑ mortality). The photo shows a grayscale ECHO showing DCMP & intraventricular thrombus.