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## Module 500: Therapeutic Agents, Anatomy, Function, and Conditions of: Musculoskeletal System ### Unit 3 - **Anticoagulant:** Prevents blood clots **Know what types of individuals aspirin is contraindicated for?** Young children and teenagers. **Know what Reye's syndrome is?** It is a life-th...

## Module 500: Therapeutic Agents, Anatomy, Function, and Conditions of: Musculoskeletal System ### Unit 3 - **Anticoagulant:** Prevents blood clots **Know what types of individuals aspirin is contraindicated for?** Young children and teenagers. **Know what Reye's syndrome is?** It is a life-threatening disorder affecting the liver and brain, but it can affect any organ. **Know what cyclooxygenase (COX) enzyme is?** - COX-1 promotes platelet aggregation, metabolic function. - COX-2 at site of injury it releases prostaglandin it is responsible for pain, heat, and inflammation that is part of the healing process. **Know what is the correct auxiliary label to be placed on the medication container for NSAIDs?** Take with food. **Know what side effects COX-1 and COX-2 inhibitors produce?** - COX-1 side effects: Gastric ulceration, bleeding, renal damage. - COX-2 side effects: long term use can result in hypertension, edema, and congestive heart failure **Know what is the mechanism of action of opioid analgesics?** They attach to the receptor site on the opioid target cell in the brain and changes the perception of pain at CNS and spinal cord level. **Know what CII narcotic analgesics cause?** Sedation and respiratory depression. **Know what conditions and symptoms are of osteoporosis?** - Systemic skeletal disease - Low bone mass and deterioration, bones become brittle and easily fracture - Danger is bone fracture - Affects postmenopausal women more. **Know what can prevent osteoporosis?** Life-style changes, exercise, diet, smoking cessation, calcium, and vitamin D supplements. **Know what 15 minutes of sunlight twice weekly can provide?** Supply of enough vitamin D for the body.