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### Antihypertensive Pharmacology - **Angiotensin II Receptor Blockers (ARBs)** - **SARTAN** - Block Angiotensin II from binding to receptors - Blocking RAAS - Less likely: hyperkalemia - No cough, better tolerated, lower mortality rate - **Adverse Effect...

### Antihypertensive Pharmacology - **Angiotensin II Receptor Blockers (ARBs)** - **SARTAN** - Block Angiotensin II from binding to receptors - Blocking RAAS - Less likely: hyperkalemia - No cough, better tolerated, lower mortality rate - **Adverse Effects:** Upper respiratory infections & hyperkalemia - **Calcium Channel Blockers (CCBs)** - ↓ BP - Treatment of HTN and Angina - First-line drugs for HTN - Blocks Calcium which blocks vasoconstriction - **DIPINE** - **Amlodipine** - **Diuretics** - ↓ VBP - First-line drugs for HTN - Decrease plasma and Extracellular fluid volume. - Reduce preload, cardiac output and systemic vascular resistance therefore decreasing workload of the heart. - **Thiazide diuretics** - hydrochlorothiazide (HCTZ) - **Loop diuretics** - furosemide (Lasix) - Common supplementation - Hypokalemia - **K-sparing diuretics** - spironolactone (Aldactone) - Hyperkalemia - **Contraindicated:** Sulfa allergy or final failure.