Cephalosporins, Carbapenems and Monobactams Quiz
65 Questions
4 Views
3.3 Stars

Cephalosporins, Carbapenems and Monobactams Quiz

Created by
@CohesiveWhale

Questions and Answers

Which class of antibiotics covers pseudomonas and contains agents that resist degradation by beta-lactamases?

Carbapenems

Which cephalosporin covers MRSA infections?

Cefepime

Which antibiotic class is characterized by having excellent coverage against Gram-negative infections including pseudomonas but lacks reliable Gram-positive or anaerobic coverage?

Monobactam

Which antibiotic class inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan?

<p>Glycopeptides</p> Signup and view all the answers

Among the following, which antibiotic is used first-line to treat C.difficile infection and MRSA bacteremia?

<p>Vancomycin</p> Signup and view all the answers

Which class of antibiotics is known to hydrolyze all ß-lactam antibiotics except aztreonam?

<p>Carbapenems</p> Signup and view all the answers

Which antibiotic class is NOT affected by clavulanic acid or tazobactam?

<p>Monobactam</p> Signup and view all the answers

Which antibiotic class is characterized by being active against Gram positive agents including MRSA but having no anaerobic coverage?

<p>Glycopeptides</p> Signup and view all the answers

Which antibiotic class has the characteristic of destroying the cell membrane by direct chemical interaction with LPS?

<p>Polymyxins</p> Signup and view all the answers

Which class of antibiotics treats rickettsial infections and is active against both Gram positive and Gram negative organisms?

<p>Tetracyclines</p> Signup and view all the answers

Which of the following cell wall inhibitors primarily targets Gram negative organisms?

<p>Fosfomycin</p> Signup and view all the answers

Which antibiotic is associated with the unique toxicity of encephalitis?

<p>Cefepime</p> Signup and view all the answers

Which class of ß-lactamases requires zinc and can hydrolyze penicillins and carbapenems?

<p>Metallo ß-lactamses</p> Signup and view all the answers

Which cell wall inhibitor is mainly used topically for wounds and burn injuries?

<p>Bacitracin</p> Signup and view all the answers

Which of the following antibiotics is NOT associated with renal toxicity?

<p>Bacitracin</p> Signup and view all the answers

What is the general mechanism of action of penicillins?

<p>Inhibition of cell wall synthesis</p> Signup and view all the answers

Which type of infection is NOT reliably covered by penicillin G and V?

<p>Staphylococcus infections</p> Signup and view all the answers

What is the main difference between oral Penicillin V and intramuscular Penicillin G?

<p>Method of administration</p> Signup and view all the answers

Which antibiotic class includes drugs like Cephalosporins and Monobactam?

<p>Penicillins</p> Signup and view all the answers

What is the primary target of Carbapenems in bacterial cells?

<p>Cell wall synthesis</p> Signup and view all the answers

Which organism is NOT covered by aminopenicillins?

<p>Staphylococcus</p> Signup and view all the answers

Why are beta-lactamases a concern in antibiotic resistance?

<p>They break down beta-lactam antibiotics</p> Signup and view all the answers

Which penicillin-based drug reliably covers streptococcus and staphylococcus infections?

<p>Oxacillin</p> Signup and view all the answers

What makes the 5th generation cephalosporins unique?

<p>They cover MRSA infections</p> Signup and view all the answers

Which class of antibiotics includes agents that cover pseudomonas infections?

<p>Carbapenems</p> Signup and view all the answers

Which antibiotic class among penicillins, monobactam, cephalosporins, glycopeptides, and carbapenems is characterized by being active against Gram positive infections, including MRSA, but lacks reliable Gram negative or anaerobic coverage?

<p>Glycopeptides</p> Signup and view all the answers

Which antibiotic class contains only one agent (Aztreonam) and has excellent coverage against Gram negative infections, including pseudomonas, but lacks reliable Gram positive or anaerobic coverage?

<p>Monobactam</p> Signup and view all the answers

Which antibiotic class is known for resisting degradation by beta-lactamases and includes agents that cover pseudomonas, with the exception of one agent (ertapenem)?

<p>Carbapenems</p> Signup and view all the answers

Among the classes of antibiotics discussed, which one inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan and prevents further elongation of cell wall polymers?

<p>Glycopeptides</p> Signup and view all the answers

Which antibiotic class is specifically highlighted as not containing a beta-lactam ring and consequently does not work by inhibiting PBP in bacterial cells?

<p>Monobactam</p> Signup and view all the answers

Which antibiotic class is known for reliably covering streptococcus and staphylococcus infections, but does NOT cover Gram-negative, anaerobic, or methicillin-resistant staphylococcus aureus (MRSA) infections?

<p>Aminopenicillins</p> Signup and view all the answers

Which beta-lactam antibiotic is unique because it has a modification in structure that makes the drug molecule bulky to resist breakdown by enzymes and reliably covers streptococcus and staphylococcus infections?

<p>Oxacillin</p> Signup and view all the answers

Among the following antibiotic classes, which one is NOT reliably covered by aminopenicillins when it comes to Pseudomonas infections?

<p>Monobactams</p> Signup and view all the answers

Which antibiotic class contains agents that are mainly used topically for wounds and burn injuries?

<p>Penicillins</p> Signup and view all the answers

Which class of antibiotics contains drugs that cover Pseudomonas infections and resist degradation by beta-lactamases?

<p>Monobactams</p> Signup and view all the answers

Which antibiotic inhibits pyruvyl-transferase, an enzyme required for cell wall synthesis?

<p>Fosfomycin</p> Signup and view all the answers

Which antibiotic class is known for causing seizures by lowering the seizure threshold?

<p>Carbapenems</p> Signup and view all the answers

What sets the 5th generation cephalosporins apart from other generations of cephalosporins in terms of their coverage?

<p>They cover MRSA infections</p> Signup and view all the answers

Which antibiotic class is mainly used to treat urinary tract infections and is active against Gram-negative organisms?

<p>Monobactams</p> Signup and view all the answers

Which antibiotic class is NOT covered in the text provided?

<p>Macrolides</p> Signup and view all the answers

Which antibiotic class is known for its activity against both Gram positive and Gram negative organisms, treating rickettsial infections, and includes drugs like Tetracyclines and Aminoglycosides?

<p>Cephalosporins</p> Signup and view all the answers

Which antibiotic class is NOT inhibited by clavulanic acid or tazobactam, has no reliable anaerobic coverage, and can hydrolyze all ß-lactam antibiotics except aztreonam?

<p>Carbapenems</p> Signup and view all the answers

Which antibiotic class includes Daptomycin that penetrates the cell membrane resulting in efflux of K+ from bacterial cell, is only active against Gram positive agents including MRSA, and cannot be used for lung infections?

<p>Glycopeptides</p> Signup and view all the answers

Which antibiotic class contains agents like Polymyxins that have detergent-like activity, destroy the cell membrane by direct chemical interaction with LPS, and are only active against Gram negative agents?

<p>Monobactam</p> Signup and view all the answers

Which antibiotic class is characterized by inhibiting protein synthesis by targeting either the 30S or 50S ribosomal subunit, and includes antibiotics like Tetracyclines and Aminoglycosides?

<p>Glycopeptides</p> Signup and view all the answers

What is the unique characteristic of Penicillin G administration?

<p>Intramuscular administration</p> Signup and view all the answers

Which type of infection is reliably covered by Penicillin V?

<p>Streptococcus infections</p> Signup and view all the answers

What is the primary mechanism of action of Monobactam antibiotics?

<p>Inhibition of cell wall synthesis</p> Signup and view all the answers

Which antibiotic class provides coverage against Gram-negative infections including Pseudomonas but lacks reliable Gram-positive or anaerobic coverage?

<p>Monobactam</p> Signup and view all the answers

What is the main difference between Penicillins and Cephalosporins?

<p>Coverage spectrum</p> Signup and view all the answers

Which antibiotic is primarily associated with the unique toxicity known as 'Gray baby syndrome'?

<p>Ampicillin/Sulbactam</p> Signup and view all the answers

Which antibiotic class includes drugs that are NOT affected by clavulanic acid or tazobactam?

<p>Monobactam</p> Signup and view all the answers

Which antibiotic class is characterized by having excellent coverage against Gram-negative infections but lacks reliable Gram-positive or anaerobic coverage?

<p>Cephalosporins</p> Signup and view all the answers

Which cell wall inhibitor is mainly used topically for wounds and burn injuries?

<p>Chloramphenicol</p> Signup and view all the answers

Which antibiotic class has the characteristic of destroying the cell membrane by direct chemical interaction with lipopolysaccharides (LPS)?

<p>Glycopeptides</p> Signup and view all the answers

Which antibiotic class is primarily used for the treatment of C.difficile infections?

<p>Cephalosporins</p> Signup and view all the answers

Which antibiotic class is known for its activity against both Gram positive and Gram negative organisms but lacks reliable anaerobic coverage?

<p>Penicillins</p> Signup and view all the answers

Which of the following antibiotic classes primarily targets MRSA and vancomycin-resistant enterococcus infections?

<p>Glycopeptides</p> Signup and view all the answers

Which antibiotic class is characterized by its activity against Gram positive organisms and anaerobes?

<p>Glycopeptides</p> Signup and view all the answers

Among the listed antibiotic classes, which one is least commonly used for antibiotic treatment according to the text?

<p>Monobactam</p> Signup and view all the answers

Which antibiotic class has been associated with a high risk of pseudomembranous colitis?

<p>Cephalosporins</p> Signup and view all the answers

Which antibiotic class is NOT typically resistant to degradation by beta-lactamases?

<p>Carbapenems</p> Signup and view all the answers

Which antibiotic class is characterized by being active against MRSA but lacking reliable coverage against Gram-negative organisms?

<p>Glycopeptides</p> Signup and view all the answers

Among Penicillins, Monobactam, Cephalosporins, and Carbapenems, which class is primarily active against Gram-positive organisms such as MRSA and anaerobes?

<p>Carbapenems</p> Signup and view all the answers

Which antibiotic class is mainly reserved for methicillin-resistant Staphylococcus aureus (MRSA) infections?

<p>Carbapenems</p> Signup and view all the answers

Study Notes

Antibiotic Classes

  • Cephalosporins that cover MRSA infections include cephalosporin antibiotics.
  • The class of antibiotics that covers pseudomonas and resists degradation by beta-lactamases is Monobactam.
  • The antibiotic class characterized by excellent coverage against Gram-negative infections, including pseudomonas, but lacking reliable Gram-positive or anaerobic coverage is Monobactam.

Cell Wall Inhibitors

  • The antibiotic class that inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan is beta-lactam antibiotics.
  • Carbapenems primarily target the cell wall of Gram-negative bacteria.

Antibiotic Resistance

  • Beta-lactamases are a concern in antibiotic resistance because they can hydrolyze beta-lactam antibiotics.

Antibiotic Characteristics

  • Aminopenicillins do not reliably cover Pseudomonas infections.
  • Penicillin G is not reliably effective against anaerobic infections.
  • The unique characteristic of Penicillin G administration is its short half-life.
  • Penicillin V reliably covers streptococcus and staphylococcus infections.
  • Cephalosporins are active against Gram-positive and Gram-negative organisms.

Specific Antibiotics

  • Metronidazole is used to treat C.difficile infections and is associated with a high risk of pseudomembranous colitis.
  • Vancomycin is used to treat MRSA bacteremia and is characterized by its activity against Gram-positive organisms and anaerobes.
  • Daptomycin is active against Gram-positive agents, including MRSA, and cannot be used for lung infections.
  • Polymyxins have detergent-like activity, destroying the cell membrane by direct chemical interaction with lipopolysaccharides (LPS), and are only active against Gram-negative agents.

Topical Antibiotics

  • Cell wall inhibitors like Polymyxins are mainly used topically for wounds and burn injuries.

Antibiotic Toxicity

  • Chloramphenicol is associated with the unique toxicity known as 'Gray baby syndrome'.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Test your knowledge on cephalosporins, carbapenems, and monobactams antibiotics. Learn which antibiotics cover pseudomonas, MRSA, contain a beta-lactam ring, resist degradation by beta-lactamases, and are combined with enzyme inhibitors.

More Quizzes Like This

Use Quizgecko on...
Browser
Browser