Cephalosporins, Carbapenems and Monobactams Quiz

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Which class of antibiotics covers pseudomonas and contains agents that resist degradation by beta-lactamases?

Carbapenems

Which cephalosporin covers MRSA infections?

Cefepime

Which antibiotic class is characterized by having excellent coverage against Gram-negative infections including pseudomonas but lacks reliable Gram-positive or anaerobic coverage?

Monobactam

Which antibiotic class inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan?

Glycopeptides

Among the following, which antibiotic is used first-line to treat C.difficile infection and MRSA bacteremia?

Vancomycin

Which class of antibiotics is known to hydrolyze all ß-lactam antibiotics except aztreonam?

Carbapenems

Which antibiotic class is NOT affected by clavulanic acid or tazobactam?

Monobactam

Which antibiotic class is characterized by being active against Gram positive agents including MRSA but having no anaerobic coverage?

Glycopeptides

Which antibiotic class has the characteristic of destroying the cell membrane by direct chemical interaction with LPS?

Polymyxins

Which class of antibiotics treats rickettsial infections and is active against both Gram positive and Gram negative organisms?

Tetracyclines

Which of the following cell wall inhibitors primarily targets Gram negative organisms?

Fosfomycin

Which antibiotic is associated with the unique toxicity of encephalitis?

Cefepime

Which class of ß-lactamases requires zinc and can hydrolyze penicillins and carbapenems?

Metallo ß-lactamses

Which cell wall inhibitor is mainly used topically for wounds and burn injuries?

Bacitracin

Which of the following antibiotics is NOT associated with renal toxicity?

Bacitracin

What is the general mechanism of action of penicillins?

Inhibition of cell wall synthesis

Which type of infection is NOT reliably covered by penicillin G and V?

Staphylococcus infections

What is the main difference between oral Penicillin V and intramuscular Penicillin G?

Method of administration

Which antibiotic class includes drugs like Cephalosporins and Monobactam?

Penicillins

What is the primary target of Carbapenems in bacterial cells?

Cell wall synthesis

Which organism is NOT covered by aminopenicillins?

Staphylococcus

Why are beta-lactamases a concern in antibiotic resistance?

They break down beta-lactam antibiotics

Which penicillin-based drug reliably covers streptococcus and staphylococcus infections?

Oxacillin

What makes the 5th generation cephalosporins unique?

They cover MRSA infections

Which class of antibiotics includes agents that cover pseudomonas infections?

Carbapenems

Which antibiotic class among penicillins, monobactam, cephalosporins, glycopeptides, and carbapenems is characterized by being active against Gram positive infections, including MRSA, but lacks reliable Gram negative or anaerobic coverage?

Glycopeptides

Which antibiotic class contains only one agent (Aztreonam) and has excellent coverage against Gram negative infections, including pseudomonas, but lacks reliable Gram positive or anaerobic coverage?

Monobactam

Which antibiotic class is known for resisting degradation by beta-lactamases and includes agents that cover pseudomonas, with the exception of one agent (ertapenem)?

Carbapenems

Among the classes of antibiotics discussed, which one inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan and prevents further elongation of cell wall polymers?

Glycopeptides

Which antibiotic class is specifically highlighted as not containing a beta-lactam ring and consequently does not work by inhibiting PBP in bacterial cells?

Monobactam

Which antibiotic class is known for reliably covering streptococcus and staphylococcus infections, but does NOT cover Gram-negative, anaerobic, or methicillin-resistant staphylococcus aureus (MRSA) infections?

Aminopenicillins

Which beta-lactam antibiotic is unique because it has a modification in structure that makes the drug molecule bulky to resist breakdown by enzymes and reliably covers streptococcus and staphylococcus infections?

Oxacillin

Among the following antibiotic classes, which one is NOT reliably covered by aminopenicillins when it comes to Pseudomonas infections?

Monobactams

Which antibiotic class contains agents that are mainly used topically for wounds and burn injuries?

Penicillins

Which class of antibiotics contains drugs that cover Pseudomonas infections and resist degradation by beta-lactamases?

Monobactams

Which antibiotic inhibits pyruvyl-transferase, an enzyme required for cell wall synthesis?

Fosfomycin

Which antibiotic class is known for causing seizures by lowering the seizure threshold?

Carbapenems

What sets the 5th generation cephalosporins apart from other generations of cephalosporins in terms of their coverage?

They cover MRSA infections

Which antibiotic class is mainly used to treat urinary tract infections and is active against Gram-negative organisms?

Monobactams

Which antibiotic class is NOT covered in the text provided?

Macrolides

Which antibiotic class is known for its activity against both Gram positive and Gram negative organisms, treating rickettsial infections, and includes drugs like Tetracyclines and Aminoglycosides?

Cephalosporins

Which antibiotic class is NOT inhibited by clavulanic acid or tazobactam, has no reliable anaerobic coverage, and can hydrolyze all ß-lactam antibiotics except aztreonam?

Carbapenems

Which antibiotic class includes Daptomycin that penetrates the cell membrane resulting in efflux of K+ from bacterial cell, is only active against Gram positive agents including MRSA, and cannot be used for lung infections?

Glycopeptides

Which antibiotic class contains agents like Polymyxins that have detergent-like activity, destroy the cell membrane by direct chemical interaction with LPS, and are only active against Gram negative agents?

Monobactam

Which antibiotic class is characterized by inhibiting protein synthesis by targeting either the 30S or 50S ribosomal subunit, and includes antibiotics like Tetracyclines and Aminoglycosides?

Glycopeptides

What is the unique characteristic of Penicillin G administration?

Intramuscular administration

Which type of infection is reliably covered by Penicillin V?

Streptococcus infections

What is the primary mechanism of action of Monobactam antibiotics?

Inhibition of cell wall synthesis

Which antibiotic class provides coverage against Gram-negative infections including Pseudomonas but lacks reliable Gram-positive or anaerobic coverage?

Monobactam

What is the main difference between Penicillins and Cephalosporins?

Coverage spectrum

Which antibiotic is primarily associated with the unique toxicity known as 'Gray baby syndrome'?

Ampicillin/Sulbactam

Which antibiotic class includes drugs that are NOT affected by clavulanic acid or tazobactam?

Monobactam

Which antibiotic class is characterized by having excellent coverage against Gram-negative infections but lacks reliable Gram-positive or anaerobic coverage?

Cephalosporins

Which cell wall inhibitor is mainly used topically for wounds and burn injuries?

Chloramphenicol

Which antibiotic class has the characteristic of destroying the cell membrane by direct chemical interaction with lipopolysaccharides (LPS)?

Glycopeptides

Which antibiotic class is primarily used for the treatment of C.difficile infections?

Cephalosporins

Which antibiotic class is known for its activity against both Gram positive and Gram negative organisms but lacks reliable anaerobic coverage?

Penicillins

Which of the following antibiotic classes primarily targets MRSA and vancomycin-resistant enterococcus infections?

Glycopeptides

Which antibiotic class is characterized by its activity against Gram positive organisms and anaerobes?

Glycopeptides

Among the listed antibiotic classes, which one is least commonly used for antibiotic treatment according to the text?

Monobactam

Which antibiotic class has been associated with a high risk of pseudomembranous colitis?

Cephalosporins

Which antibiotic class is NOT typically resistant to degradation by beta-lactamases?

Carbapenems

Which antibiotic class is characterized by being active against MRSA but lacking reliable coverage against Gram-negative organisms?

Glycopeptides

Among Penicillins, Monobactam, Cephalosporins, and Carbapenems, which class is primarily active against Gram-positive organisms such as MRSA and anaerobes?

Carbapenems

Which antibiotic class is mainly reserved for methicillin-resistant Staphylococcus aureus (MRSA) infections?

Carbapenems

Study Notes

Antibiotic Classes

  • Cephalosporins that cover MRSA infections include cephalosporin antibiotics.
  • The class of antibiotics that covers pseudomonas and resists degradation by beta-lactamases is Monobactam.
  • The antibiotic class characterized by excellent coverage against Gram-negative infections, including pseudomonas, but lacking reliable Gram-positive or anaerobic coverage is Monobactam.

Cell Wall Inhibitors

  • The antibiotic class that inhibits cell wall synthesis by binding the terminal molecule of the peptidoglycan is beta-lactam antibiotics.
  • Carbapenems primarily target the cell wall of Gram-negative bacteria.

Antibiotic Resistance

  • Beta-lactamases are a concern in antibiotic resistance because they can hydrolyze beta-lactam antibiotics.

Antibiotic Characteristics

  • Aminopenicillins do not reliably cover Pseudomonas infections.
  • Penicillin G is not reliably effective against anaerobic infections.
  • The unique characteristic of Penicillin G administration is its short half-life.
  • Penicillin V reliably covers streptococcus and staphylococcus infections.
  • Cephalosporins are active against Gram-positive and Gram-negative organisms.

Specific Antibiotics

  • Metronidazole is used to treat C.difficile infections and is associated with a high risk of pseudomembranous colitis.
  • Vancomycin is used to treat MRSA bacteremia and is characterized by its activity against Gram-positive organisms and anaerobes.
  • Daptomycin is active against Gram-positive agents, including MRSA, and cannot be used for lung infections.
  • Polymyxins have detergent-like activity, destroying the cell membrane by direct chemical interaction with lipopolysaccharides (LPS), and are only active against Gram-negative agents.

Topical Antibiotics

  • Cell wall inhibitors like Polymyxins are mainly used topically for wounds and burn injuries.

Antibiotic Toxicity

  • Chloramphenicol is associated with the unique toxicity known as 'Gray baby syndrome'.

Test your knowledge on cephalosporins, carbapenems, and monobactams antibiotics. Learn which antibiotics cover pseudomonas, MRSA, contain a beta-lactam ring, resist degradation by beta-lactamases, and are combined with enzyme inhibitors.

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