10 Questions
What is the main function of the urea cycle?
Excretion of nitrogen in the form of urea
How is excess nitrogen eliminated in the body?
Through the urea cycle
What happens to the concentration of urea-cycle enzymes with long-term changes in dietary protein?
It can change by 20-fold or greater
In conditions of starvation, why do enzyme levels in the urea cycle rise?
Due to proteins being degraded for energy
What is cirrhosis of the liver and where does it rank in causes of death for the 45–65 age group?
It is the third most common cause of death after heart disorders and cancer
What are the most common causes of cirrhosis in the Western world?
Chronic alcoholism and hepatitis C
What is the significance of glutamate dehydrogenase and glutamine synthetase in peripheral tissues?
They are important for removing reduced nitrogen
How is reduced nitrogen primarily removed in the brain?
By glutamate dehydrogenase and glutamine synthetase
What does the statement 'The urea cycle operates only to eliminate excess nitrogen' imply?
Urea cycle functions to maintain nitrogen balance
How do urea-cycle enzymes respond to changes in dietary protein levels?
Enzyme levels can change significantly based on protein intake
Test your knowledge on the metabolism of bilirubin in the liver including the conversion to water-soluble forms through glucuronidation. Learn about the process of forming conjugated bilirubin and its significance in elimination.
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