Antipsychotcics quiz 1

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73 Questions

An increase in dopamine in the mesocortical pathway leads to positive symptoms of schizophrenia.

False

The Tuberoinfundibular pathway in schizophrenia shows an increase in dopamine levels.

False

Dementia is one of the medical conditions that can present with psychosis.

True

Schizophrenia onset typically begins around the age of 30.

False

Typical antipsychotics primarily act as serotonin agonists.

False

Atypical antipsychotics are considered first generation.

False

Neuroleptic malignant syndrome (NMS) is not a medical emergency.

False

NMS symptoms include hypotension and hypoglycemia.

False

Extrapyramidal symptoms include akathisia, dystonia, and tardive dyskinesia.

True

Akathisia usually presents with a slow onset over months to years.

False

Pseudo-parkinsonism symptoms include tremor, bradykinesia, and shuffled gait.

True

Tardive dyskinesia can occur within days to weeks of starting treatment.

False

Ziprasidone dosing includes once a day oral capsule and immediate IM injection.

False

Pimavanserin is FDA approved for the treatment of Parkinson's Disease psychosis.

True

VMAT2 inhibitors include haloperidol and aripiprazole.

False

Iglami formulations include IV and subcutaneous injection.

False

Hyperprolactinemia due to dopamine antagonism can cause menstrual disturbances and gynecomastia.

True

Risperidone long-acting injectable Perseris is given every two weeks.

False

Typical antipsychotics are mainly beneficial for reducing negative symptoms of schizophrenia.

False

The main benefit of Ziprasidone is its high efficacy in treating metabolic syndrome.

False

Treatment-resistant schizophrenia is defined as a lack of symptom improvement despite trials of antipsychotics from the same class.

False

Lumateperon is recommended in severe hepatic impairment.

False

Olanzapine/samidorphan dosing involves adding 5 mg of samidorphan to the standard olanzapine dose.

False

Haloperidol Decanoate is given every 2 weeks.

False

Fluphenazine Decanoate has a long onset of action and oral overlap is necessary.

False

Quetiapine is commonly used in the treatment of ICU delirium and sleep disorders.

True

Lurasidone must be taken on an empty stomach for optimal bioavailability.

False

Aripiprazole is a full agonist of dopamine and serotonin receptors.

False

Cariprazine has a moderate risk of weight gain compared to aripiprazole.

True

Asenapine sublingual tablet should be swallowed with water.

False

Brexpiprazole has no dose adjustments needed in renal or hepatic impairment.

False

Paliperidone should be avoided in individuals with hypersensitivity to risperidone.

True

Lurasidone is contraindicated with strong CYP3A4 inhibitors.

True

Haloperidol carries a high risk of sedation as an adverse effect.

False

Clozapine must be offered before considering other treatment options.

False

Fluphenazine formulations include oral tablet only.

False

Zyprexa Relprevv has a black box warning related to post-injection delirium/sedation syndrome.

True

Aripiprazole can increase prolactin levels.

False

Quetiapine should be taken on an empty stomach for best results.

False

Asenapine patch should be worn for 48 hours before replacing with a new one.

False

Iloperidone interacts with CYP450 CYP2D6 CYP3A4 enzymes.

True

Haloperidol Decanoate maintenance dose is typically 5 times the oral dose.

False

BBW for Loxapine includes risk of QT prolongation.

False

Which of the following substances is NOT listed as exacerbating psychosis in the text?

Benzodiazepines

What are the minimum number of the following required for a schizophrenia diagnosis according to the DSM-5?

2

In the mesolimbic system, an increase in dopamine causes which type of symptoms in schizophrenia?

Positive

Which pathway in schizophrenia shows a decrease in dopamine levels and is associated with extrapyramidal side effects (EPS) and Tardive Dyskinesia?

Nigrostriatal pathway

Which antipsychotic medication requires dose adjustments for both hepatic and renal impairment?

Ziprasidone

What is the main warning associated with Risperidone use?

Increased risk of QTc prolongation

What is the primary benefit of Ziprasidone?

Low risk for metabolic abnormalities

What is the main treatment recommendation for individuals with treatment-resistant schizophrenia?

Clozapine

Atypical antipsychotics primarily antagonize which neurotransmitters?

Dopamine and serotonin

What is a common short-term effect of hyperprolactinemia due to dopamine antagonism?

Gynecomastia

Which symptom is characteristic of pseudo-parkinsonism induced by antipsychotics?

Rigidity

What is the primary mechanism of action of typical antipsychotics?

Dopamine antagonism

Which treatment is recommended for akathisia induced by antipsychotic medications?

Propranolol

What is the first-line treatment choice for individuals with schizophrenia?

Atypical antipsychotics

Which condition is a Black Box Warning associated with in all antipsychotic medications?

[NMS] Neuroleptic Malignant Syndrome

Which treatment is used for the long-term management of tardive dyskinesia?

Velbenazine

In what pathway does an increase in dopamine levels lead to positive symptoms of schizophrenia?

Mesolimbic pathway

What is the first-line treatment recommended for acute agitation and aggression?

Non-pharmacologic interventions

Which atypical antipsychotic is known for causing a high risk of extrapyramidal symptoms (EPS)?

Loxapine

How often is Haloperidol Decanoate typically administered?

Every 4 weeks

What is the black box warning associated with Loxapine?

Bronchospasm with inhalation (REMS)

Which atypical antipsychotic has a unique adverse effect of metallic taste and tongue numbness when taken sublingually?

Asenapine

What is the mechanism of action of Aripiprazole?

Dopamine and serotonin partial agonist

Which antipsychotic has the highest risk of metabolic syndrome?

Olanzapine

Which antipsychotic requires dose titration due to orthostatic hypotension?

Iloperidone

Which antipsychotic is contraindicated in patients with hypersensitivity to risperidone?

Paliperidone

Which antipsychotic does NOT includes an ODT option?

Lumateperon

Which antipsychotic has a BBW (Black Box Warning) for severe neutropenia?

Clozapine

Which antipsychotic is known for requiring a 350 kcal meal for optimal bioavailability?

Lurasidone

Which antipsychotic formulation includes an oral tablet, ODT, and suspension options?

Clozapine

Explore the benefits of Long-Acting Injectable medications for improving adherence and reducing risks in psychiatry, along with first and second-line interventions for acute agitation and aggression. Learn about non-pharmacological approaches, de-escalation techniques, and pharmacological options like antipsychotics and benzodiazepines.

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