Questions and Answers
In tissue rejection, which route involves donor dendritic cells directly presenting antigens to recipient T cells?
Which type of MHC molecules are most frequently recognized by alloantibodies generated from alloreactive B cells?
What is the prime target of graft vasculature in tissue rejection?
Which cells capture and process donor alloantigens and then present them to recipient T cells in the indirect pathway of tissue rejection?
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What is the key function of alloreactive antibodies in tissue rejection?
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Where do antigens presented by both donor and recipient APCs travel to in the rejection process?
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Which molecule expressed by endothelial cells serves as a target for graft vasculature in tissue rejection?
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What is the consequence of alloantibodies recognizing graft antigens in tissue rejection?
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What is the primary role of CD8+ cytotoxic T cells in transplant rejection?
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How do CD4+ helper T cells contribute to tissue rejection in transplants?
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What is the role of alloreactive B cells in response to alloantigens?
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Which immune cells are responsible for directly attacking and killing graft tissue cells?
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How do alloantigen-specific antibodies contribute to tissue rejection?
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Which component is a prime target for the recipient's immune response in transplant rejection?
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What is the ultimate consequence of an attack on the vasculature of transplanted tissue?
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What effect do antibodies targeting MHC proteins have on the donated tissue?
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What is the main way activated effector T cells contribute to transplant rejection?
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Which pathway involves the recipient dendritic cells capturing and processing donor alloantigens in tissue rejection?
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What is the primary function of effector T cells in transplant rejection?
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Which immune cells are primarily involved in the differentiation into effector T cells after antigen presentation in the lymph node response?
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In transplant rejection, what is the direct consequence of donor dendritic cells directly presenting antigens to recipient T cells?
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What is the crucial function of recipient APCs in the indirect pathway of tissue rejection?
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What is a significant outcome of antigens being presented to naive T cells in the lymph nodes during tissue rejection?
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How do effector T cells contribute differently from naive T cells to tissue rejection?
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What role do CD4+ helper T cells play in transplant rejection?
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Which effector mechanisms can separately or in combination promote allograft rejection?
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What is the primary function of alloreactive B cells in response to alloantigens?
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What is the consequence of an attack on the vasculature of transplanted tissue?
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Which component plays a crucial role in orchestrating an immune response against transplanted tissue?
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What is the role of CD8+ cytotoxic T cells in allograft rejection?
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How do antibodies produced by alloreactive B cells contribute to tissue rejection?
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In transplant rejection, what is a prime target for the recipient's immune response?
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What is crucial for developing strategies to prevent or mitigate rejection and improve transplant outcomes?
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