Which system is used to reprogram somatic cells into iPSCs?
Understand the Problem
The question is asking about the different systems used for reprogramming somatic cells into induced Pluripotent Stem Cells (iPSCs), with multiple options provided for the answer. The response will involve identifying the correct method from the given options.
Answer
Drug inducible transgenic system using factors like Oct4, Sox2, Klf4, and c-Myc.
Somatic cells are reprogrammed into iPSCs using a drug inducible transgenic system, often involving lentiviral introduction of factors like Oct4, Sox2, Klf4, and c-Myc.
Answer for screen readers
Somatic cells are reprogrammed into iPSCs using a drug inducible transgenic system, often involving lentiviral introduction of factors like Oct4, Sox2, Klf4, and c-Myc.
More Information
Reprogramming somatic cells into iPSCs often involves the use of viral vectors to introduce specific transcription factors that activate pluripotency genes.
Tips
A common mistake is to confuse the vectors used for gene delivery (viral vectors) with the inducing factors (Oct4, Sox2, Klf4, and c-Myc).
Sources
- The web page with info on - Example Source - pmc.ncbi.nlm.nih.gov
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