Which statement best describes the interaction between GABA B2 and GABA?
Understand the Problem
The question is asking to identify the correct statement that describes the interaction between GABA B2 and GABA, focusing on their functional relationship.
Answer
GABA B2 is essential for G protein coupling in the GABA B receptor.
The interaction between GABA B2 and GABA involves GABA B2 being essential for G protein coupling of the GABA B receptor heterodimer, which includes both GABA B1 and GABA B2 subunits.
Answer for screen readers
The interaction between GABA B2 and GABA involves GABA B2 being essential for G protein coupling of the GABA B receptor heterodimer, which includes both GABA B1 and GABA B2 subunits.
More Information
The GABA B receptor is a heterodimer consisting of GABA B1 and GABA B2 subunits. GABA B2 plays a crucial role in ensuring the proper coupling of the receptor to G proteins, which is needed for signal transduction.
Tips
A common mistake is confusing GABA B2's role with its location; it does not independently mediate inhibitory action but facilitates it through interaction with GABA B1.
Sources
- Structure and functional interaction of the extracellular domain of... - ncbi.nlm.nih.gov
- Signal Transduction by GABA B Receptor Heterodimers - Nature - nature.com
- Allosteric interactions between GB1 and GB2 subunits are required... - embopress.org
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