Which ratio indicates favored absorption for a weak acid drug in a highly acidic environment?
Understand the Problem
The question is asking which ratio of ionized to nonionized forms of a weak acid drug favors its absorption in a highly acidic environment. It is likely referring to the principles of acid-base chemistry and drug absorption.
Answer
Higher un-ionized to ionized ratio.
The ratio that indicates favored absorption for a weak acid drug in a highly acidic environment is the ratio of un-ionized to ionized forms, which is higher in more acidic environments.
Answer for screen readers
The ratio that indicates favored absorption for a weak acid drug in a highly acidic environment is the ratio of un-ionized to ionized forms, which is higher in more acidic environments.
More Information
In an acidic environment like the stomach, weak acids are more likely to exist in an un-ionized form, which is better absorbed through biological membranes.
Tips
A common mistake is confusing un-ionized and ionized forms. Un-ionized forms are better absorbed as they are more lipid-soluble.
Sources
- Drug Absorption - Clinical Pharmacology - Merck Manuals - merckmanuals.com
- Drug Absorption - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Drug absorption | Pharmacology Education Project - pharmacologyeducation.org
AI-generated content may contain errors. Please verify critical information
