Which of the following describes the role of cAMP in the activation of Protein Kinase A (PKA)? A) cAMP inhibits the activity of PKA. B) cAMP binds to the regulatory subunits leadin... Which of the following describes the role of cAMP in the activation of Protein Kinase A (PKA)? A) cAMP inhibits the activity of PKA. B) cAMP binds to the regulatory subunits leading to dissociation. C) cAMP acts as a substrate for PKA. D) cAMP directly phosphorylates target proteins.
Understand the Problem
The question is asking us to identify the correct function of cAMP in relation to the activation of Protein Kinase A (PKA) from the given options.
Answer
B) cAMP binds to the regulatory subunits leading to dissociation.
The final answer is B) cAMP binds to the regulatory subunits leading to dissociation.
Answer for screen readers
The final answer is B) cAMP binds to the regulatory subunits leading to dissociation.
More Information
cAMP functions as a secondary messenger that is crucial in many signaling pathways. When cAMP binds to the regulatory subunits of PKA, it causes a conformational change and their dissociation from the catalytic subunits, thereby activating PKA.
Tips
One common mistake is to confuse the role of cAMP with other protein kinases or substrates. Remember, cAMP functions as a signaling molecule, not as a substrate or direct inhibitor.
Sources
- Protein kinase A - Wikipedia - en.wikipedia.org
- The cAMP/Protein Kinase A Pathway Regulates Virulence and ... - frontiersin.org
- Protein Kinase A - an overview | ScienceDirect Topics - sciencedirect.com
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