Which modification to a therapeutic antibody would be most effective in extending its duration of action in the body?

Understand the Problem

The question is asking about antibody engineering strategies to extend the duration of action (half-life) of a therapeutic antibody in the body. It requires understanding the mechanisms that influence antibody persistence in circulation.

More Information

The YTE modification is a specific change made to the Fc region of an antibody. The Fc region interacts with the neonatal Fc receptor (FcRn), which protects antibodies from degradation and helps recycle them back into circulation. The YTE modification enhances this interaction, leading to a longer half-life and extended duration of action for the therapeutic antibody.

Tips

It is important to specify which part of the antibody is modified. While other modifications like humanization or altering payload potency exist, YTE modification is explicitly designed to extend the duration of action.

Sources

• Rationale: YTE modification of the crystallizable fragment (Fc) portion of monoclonal antibodies (mAbs) was developed to extend their half-life and duration of action, which may reduce treatment burden for patients. - atsjournals.org