Which cytochrome P450 isoform oxidizes paracetamol to benzoquinoneamine?
Understand the Problem
The question is asking which specific cytochrome P450 isoform is responsible for the oxidation of paracetamol to benzoquinoneamine. This involves understanding both the metabolic pathway of paracetamol and the functions of different cytochrome P450 isoforms.
Answer
CYP2E1
The final answer is CYP2E1.
Answer for screen readers
The final answer is CYP2E1.
More Information
Cytochrome P450 2E1 (CYP2E1) is the main enzyme responsible for the oxidation of paracetamol to the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), which is involved in the drug's hepatotoxicity.
Sources
- PharmGKB summary: Pathways of acetaminophen metabolism at - ncbi.nlm.nih.gov
- The paracetamol metabolite N-acetylp-benzoquinone imine - PAIN - journals.lww.com
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