Where does the folding and assembly of MHC class 1 molecules primarily take place?
Understand the Problem
The question is asking about the cellular location where MHC class 1 molecules undergo folding and assembly. The focus is on understanding cellular processes related to protein formation, specifically within the immune system context.
Answer
endoplasmic reticulum (ER) lumen
The folding and assembly of MHC class I molecules primarily take place in the endoplasmic reticulum (ER) lumen.
Answer for screen readers
The folding and assembly of MHC class I molecules primarily take place in the endoplasmic reticulum (ER) lumen.
More Information
This is a crucial step in the MHC class I antigen presentation pathway as it ensures the proper folding and loading of peptides necessary for immune recognition.
Tips
A common mistake is confusing the folding location of MHC class I with other cellular locations where different parts of antigen processing occur, such as cytosol or endosomes.
Sources
- PMC: MHC class I molecule assembly - ncbi.nlm.nih.gov
- Wikipedia: MHC class I - en.wikipedia.org
- ScienceDirect: Overview on MHC class I - sciencedirect.com
