What is the synthesis of sulphonamides from 4-nitrobenzenesulfonyl chloride?
Understand the Problem
The question is asking about the synthesis of sulphonamides from 4-nitrobenzenesulfonyl chloride, detailing the reactions involving certain reagents such as NO2, RN, and Zn along the reaction pathway. It is focusing on the chemical transformations involved in this synthetic process.
Answer
React with amine, reduce NO₂ to NH₂ using Zn/[H].
The synthesis involves reacting 4-nitrobenzenesulfonyl chloride with an amine to form sulfonamide, followed by reducing the nitro group to an amino group using Zn/[H].
Answer for screen readers
The synthesis involves reacting 4-nitrobenzenesulfonyl chloride with an amine to form sulfonamide, followed by reducing the nitro group to an amino group using Zn/[H].
More Information
This synthesis efficiently creates sulfonamides, a key structure in pharmaceuticals, by a straightforward process involving amine reaction and nitro group reduction.
Tips
Ensure the complete reduction of the nitro group to amine to avoid unwanted side reactions.
Sources
- Convenient synthesis of primary sulfonamides - ScienceDirect.com - sciencedirect.com
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