What is the role of the RAG-1 and RAG-2 enzymes in immunoglobulin gene segment recombination?
Understand the Problem
The question is asking about the specific functions of the RAG-1 and RAG-2 enzymes in the context of immunoglobulin gene segment recombination, which is a crucial process for the immune system's ability to produce a diverse range of antibodies.
Answer
The RAG-1 and RAG-2 enzymes initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.
The RAG-1 and RAG-2 enzymes initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.
Answer for screen readers
The RAG-1 and RAG-2 enzymes initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.
More Information
RAG-1 and RAG-2 enzymes are integral to the adaptive immune system, facilitating the diversity of immunoglobulins and T-cell receptors by performing crucial DNA cutting tasks.
Sources
- The RAG proteins in V(D)J recombination: more than just a nuclease - ncbi.nlm.nih.gov
- Recombination-Activating Gene - an overview | ScienceDirect Topics - sciencedirect.com
- Recombination-activating gene - Wikipedia - en.wikipedia.org
