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What is the role of the RAG-1 and RAG-2 enzymes in immunoglobulin gene segment recombination?

Understand the Problem

The question is asking about the specific functions of the RAG-1 and RAG-2 enzymes in the context of immunoglobulin gene segment recombination, which is a crucial process for the immune system's ability to produce a diverse range of antibodies.

Answer

The RAG-1 and RAG-2 enzymes initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.

The RAG-1 and RAG-2 enzymes initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.

Answer for screen readers

The RAG-1 and RAG-2 enzymes initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.

More Information

RAG-1 and RAG-2 enzymes are integral to the adaptive immune system, facilitating the diversity of immunoglobulins and T-cell receptors by performing crucial DNA cutting tasks.

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