What is the primary mechanism by which alpha-2 agonists enhance analgesia during neuroaxial anesthesia?
Understand the Problem
The question is asking about the mechanism of action of alpha-2 agonists in the context of neuroaxial anesthesia, specifically how they enhance analgesia. It presents multiple-choice options that relate to different effects these agonists may have on the anesthesia process.
Answer
Activation of dorsal horn receptors in the spinal cord leading to blockage of potassium and calcium channels.
The primary mechanism by which alpha-2 agonists enhance analgesia during neuroaxial anesthesia is by activating dorsal horn receptors in the spinal cord, leading to the blockage of potassium and calcium channels, which inhibits nociceptive receptors and substance P.
Answer for screen readers
The primary mechanism by which alpha-2 agonists enhance analgesia during neuroaxial anesthesia is by activating dorsal horn receptors in the spinal cord, leading to the blockage of potassium and calcium channels, which inhibits nociceptive receptors and substance P.
More Information
Alpha-2 agonists are significant in clinical anesthesia because they offer sedation and analgesia by blocking specific pathways in the spinal cord.
Tips
A common mistake is confusing the central and peripheral mechanisms of action. Focus on the spinal cord effects for neuroaxial anesthesia.
Sources
- Use of α2-Agonists in Neuroanesthesia: An Overview - PMC - NCBI - ncbi.nlm.nih.gov
- Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical ... - ncbi.nlm.nih.gov
- Alpha-2 Agonists - VASG.org - vasg.org
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