What is the pathogenesis of edema in patients with acute diffuse glomerulonephritis?
Understand the Problem
The question is seeking an explanation for the pathogenesis of edema in patients with acute diffuse glomerulonephritis, focusing on the mechanisms involved such as changes in blood volume, osmotic pressure, capillary permeability, and sodium reabsorption.
Answer
Decreased GFR causing salt and water retention, increased hydrodynamic pressure, decreased colloid osmotic pressure, increased capillary permeability, and enhanced water and sodium reabsorption.
The pathogenesis of edema in patients with acute diffuse glomerulonephritis involves decreased GFR leading to salt and water retention (influenced by the renin-angiotensin-aldosterone system), increased hydrodynamic pressure, decreased colloid osmotic pressure of blood, increased capillary permeability, and enhanced water and sodium reabsorption.
Answer for screen readers
The pathogenesis of edema in patients with acute diffuse glomerulonephritis involves decreased GFR leading to salt and water retention (influenced by the renin-angiotensin-aldosterone system), increased hydrodynamic pressure, decreased colloid osmotic pressure of blood, increased capillary permeability, and enhanced water and sodium reabsorption.
More Information
Edema in acute diffuse glomerulonephritis is multifactorial, involving hemodynamic changes, protein loss affecting osmotic balance, and enhanced sodium reabsorption influenced by hormonal changes.
Tips
A common mistake is to overlook the systemic involvement in the condition, as edema is not solely caused by kidney issues but also by related systemic changes.
Sources
- Pathogenesis of Edema in Renal Diseases - journals.sagepub.com
- Acute Glomerulonephritis - Medscape Reference - emedicine.medscape.com
- Diffuse Proliferative Glomerulonephritis - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
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