What is the mechanism of action of clindamycin?
Understand the Problem
The question is asking for the specific way in which clindamycin works to exert its effects, particularly in the context of its pharmacological action. We are looking to identify which of the provided options accurately describes its mechanism of action.
Answer
Clindamycin inhibits protein synthesis by binding to the 50S ribosomal subunit.
Clindamycin inhibits protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. It can be bacteriostatic or bactericidal depending on concentration and other factors.
Answer for screen readers
Clindamycin inhibits protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. It can be bacteriostatic or bactericidal depending on concentration and other factors.
More Information
Clindamycin can act as either a bacteriostatic agent or bactericidal, depending on concentration, type of bacteria, and infection location. Its effectiveness is due to its ability to bind reversibly to the 50S subunit, halting bacterial growth by stopping protein synthesis.
Tips
A common mistake is not realizing that clindamycin's effect varies with dose; it can be bacteriostatic or bactericidal based on the drug concentration.
Sources
- Mechanism of Action Clindamycin - NCBI - ncbi.nlm.nih.gov
- Clindamycin: Uses, Interactions, Mechanism of Action - DrugBank - go.drugbank.com
- Clindamycin - an overview | ScienceDirect Topics - sciencedirect.com
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