What enzyme joins DNA fragments?

Understand the Problem

The question is asking about a specific enzyme that plays a role in DNA replication or repair by joining DNA fragments together. This involves understanding the biochemical processes related to DNA manipulation.

Answer

DNA ligase

DNA ligase joins DNA fragments by catalyzing the formation of a phosphodiester bond.

More Information

DNA ligase is critical in DNA replication and repair, ensuring genetic continuity across cellular generations.

Tips

A common mistake is confusing DNA ligase with DNA polymerase, which synthesizes new DNA strands but does not join fragments.

Sources

DNA ligase - Wikipedia - en.wikipedia.org
Enzymatic Assembly of Overlapping DNA Fragments - PMC - NCBI - ncbi.nlm.nih.gov
Ligase - an overview | ScienceDirect Topics - sciencedirect.com

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