What effect did sucrose ingestion have on ChREBP−/− mice?
Understand the Problem
The question is asking about the specific effects of sucrose ingestion on a genetically modified mouse model (ChREBP−/− mice). It is testing knowledge related to physiology and metabolism in a biological context.
Answer
Sucrose ingestion resulted in cecal enlargement, diarrhea, and body weight loss in ChREBP−/− mice.
The final answer is that sucrose ingestion in ChREBP−/− mice caused cecal enlargement, diarrhea, and body weight loss.
Answer for screen readers
The final answer is that sucrose ingestion in ChREBP−/− mice caused cecal enlargement, diarrhea, and body weight loss.
More Information
ChREBP-knockout mice are used to study the metabolic consequences of lacking the carbohydrate response element-binding protein. These mice show significant adverse effects when exposed to sucrose, highlighting the protein's role in sugar metabolism.
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