What effect can metabolic induction have on a drug's action?
Understand the Problem
The question is asking about the effects of metabolic induction on a drug's action, specifically exploring how it influences factors such as the drug's intensity, duration, and potency. This involves an understanding of pharmacology and how metabolic processes affect drug interaction within the body.
Answer
Metabolic induction reduces drug efficacy by increasing clearance.
Metabolic induction increases the activity of enzymes that metabolize drugs, leading to faster clearance and reduced serum concentrations, which often results in decreased drug efficacy.
Answer for screen readers
Metabolic induction increases the activity of enzymes that metabolize drugs, leading to faster clearance and reduced serum concentrations, which often results in decreased drug efficacy.
More Information
Enzyme induction can have significant clinical implications, as it may necessitate dosage adjustments to maintain therapeutic drug levels. It can also affect drug interactions and lead to ineffective treatment.
Tips
A common mistake is assuming increased enzyme activity always results in increased drug action; in fact, it typically decreases efficacy unless the drug is a pro-drug.
Sources
- Induction of drug metabolising enzymes: pharmacokinetic ... - PubMed - pubmed.ncbi.nlm.nih.gov
- Understanding enzyme or transporter-based drug interactions – SPS - sps.nhs.uk
- Drug Metabolism - News-Medical - news-medical.net
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