Which compound is primarily involved in the phase II glucuronidation reaction?
Understand the Problem
The question is asking which compound is primarily involved in the phase II glucuronidation reaction, a process in drug metabolism and detoxification. This requires knowledge about biochemical pathways and the specific roles of the compounds listed.
Answer
Glucuronic acid.
The compound primarily involved in the phase II glucuronidation reaction is glucuronic acid.
Answer for screen readers
The compound primarily involved in the phase II glucuronidation reaction is glucuronic acid.
More Information
In glucuronidation, glucuronic acid acts as a conjugating agent, aiding in the detoxification and elimination of drugs and other substances in the liver. This process is catalyzed by UDP-glucuronosyltransferase enzymes.
Tips
A common mistake is confusing the co-substrate involved in conjugation with the enzyme catalyzing the reaction. While UDP-glucuronosyltransferase is the enzyme, glucuronic acid is the compound.
Sources
- Glucuronidation - an overview | ScienceDirect Topics - sciencedirect.com
- Phase II Drug Metabolism | IntechOpen - intechopen.com
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