What do cytokine receptors primarily associate with to activate STATs?
Understand the Problem
The question is asking about the primary association of cytokine receptors to activate STAT proteins, specifically which type of kinases are involved in this process. The answer will be based on understanding the biochemical pathways related to cytokine signaling.
Answer
Janus Kinases (JAKs).
Cytokine receptors primarily associate with Janus Kinases (JAKs) to activate STATs.
Answer for screen readers
Cytokine receptors primarily associate with Janus Kinases (JAKs) to activate STATs.
More Information
Cytokine receptors upon binding with cytokines transactivate the associated JAKs. Activated JAKs phosphorylate receptor tyrosines, which subsequently recruit and activate STAT proteins, playing a crucial role in signaling pathways that regulate various immune functions.
Tips
A common confusion is mistaking the initial cytokine-receptor binding event with the downstream signaling components. It's crucial to differentiate between the receptor and its associated kinases.
Sources
- The web page with info on - Janus Kinases - pmc.ncbi.nlm.nih.gov
- Cytokine Receptor - an overview | ScienceDirect Topics - sciencedirect.com
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