What are the differences between the cells that make up the inner and outer regions of the prostate in relation to their hormone responses?
Understand the Problem
The question is asking about the differences between the cells that make up the two regions of the prostate, specifically in relation to their responses to hormones like testosterone and estrogen.
Answer
Inner regions express androgen receptors; outer regions may undergo atrophy under hormone changes.
The inner regions of the prostate, such as the luminal cells, generally respond to androgens by expressing androgen receptors and are involved in fluid secretion. The outer regions, such as periurethral glands, may undergo atrophy or squamous metaplasia following androgen withdrawal or estrogen challenge.
Answer for screen readers
The inner regions of the prostate, such as the luminal cells, generally respond to androgens by expressing androgen receptors and are involved in fluid secretion. The outer regions, such as periurethral glands, may undergo atrophy or squamous metaplasia following androgen withdrawal or estrogen challenge.
More Information
The luminal cells in the prostate are primarily responsive to androgens, playing a crucial role in the maintenance of normal prostate function and structure. In contrast, the outer or periurethral regions are sensitive to hormonal changes, often affecting their structure.
Tips
A common mistake is assuming all cells in the prostate respond to hormones in the same way. It's important to recognize the diversity in cellular response based on prostate zones.
Sources
- Prostate Tissue - an overview | ScienceDirect Topics - sciencedirect.com
- Review of Prostate Anatomy and Embryology and the Etiology of BPH - pmc.ncbi.nlm.nih.gov
- Prostate Cell - an overview | ScienceDirect Topics - sciencedirect.com
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