What are the actions of PGE2 at different receptors like EP1, EP2, EP3, and EP4?
Understand the Problem
The question appears to be regarding the actions of PGE2 and its interaction with various receptors including EP1, EP2, EP3, and EP4. It asks about the effects associated with these receptors, specifically in the context of muscle contraction and other physiological responses.
Answer
EP1: muscle contraction; EP2: broncho/vasodilation; EP3: muscle contraction, lipolysis inhibition; EP4: relaxation, cervical ripening.
The actions of PGE2 at its receptors are: EP1 causes contraction of smooth muscles; EP2 leads to bronchodilation and vasodilation; EP3 is involved in smooth muscle contraction and inhibition of lipolysis; EP4 is similar to EP2, causing relaxation and cervical ripening.
Answer for screen readers
The actions of PGE2 at its receptors are: EP1 causes contraction of smooth muscles; EP2 leads to bronchodilation and vasodilation; EP3 is involved in smooth muscle contraction and inhibition of lipolysis; EP4 is similar to EP2, causing relaxation and cervical ripening.
More Information
PGE2 has diverse physiological roles depending on the receptor subtype it binds to, influencing processes like inflammation, smooth muscle activity, and immune responses.
Tips
A common mistake is confusing the specific actions of each subtype due to their overlapping roles in different tissues.
Sources
- Role of Prostaglandin E Receptor Subtypes - academic.oup.com
- Prostaglandin E2 Receptor - ScienceDirect Topics - sciencedirect.com
- Prostaglandin E2 receptors regulate cellular immune response - JCI - jci.org
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