Under which conditions is ribose 5-phosphate biosynthesis favored over NADPH production?
Understand the Problem
The question is asking about the conditions that influence the biosynthesis of ribose 5-phosphate in relation to the production of NADPH. We need to analyze the provided options to determine which condition would favor ribose 5-phosphate production over NADPH.
Answer
Ribose 5-phosphate biosynthesis is favored when there's a high demand for nucleotide synthesis, such as in rapidly dividing cells.
Ribose 5-phosphate biosynthesis is favored over NADPH production when there is a high demand for nucleotide and nucleic acid synthesis, or when the cell is rapidly dividing. This situation diverts the majority of the glucose flux through the pentose phosphate pathway towards ribose 5-phosphate production.
Answer for screen readers
Ribose 5-phosphate biosynthesis is favored over NADPH production when there is a high demand for nucleotide and nucleic acid synthesis, or when the cell is rapidly dividing. This situation diverts the majority of the glucose flux through the pentose phosphate pathway towards ribose 5-phosphate production.
More Information
The pentose phosphate pathway (PPP) adjusts its metabolic flux based on cellular demands. During periods of rapid growth or when high levels of nucleotides are necessary, cells will channel metabolites toward ribose 5-phosphate production over NADPH generation.
Tips
A common mistake is not considering the metabolic needs of the cell, such as growth or oxidative stress, which determine the direction of the pentose phosphate pathway flux.
Sources
- Ribose 5-phosphate - Wikipedia - en.wikipedia.org
- The pentose phosphate pathway in health and disease - ludwigcancer.princeton.edu
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