This impermeability is determined by both size and charge, with proteins smaller than albumin (68 kDa) being filtered, and positively charged molecules being filtered more readily... This impermeability is determined by both size and charge, with proteins smaller than albumin (68 kDa) being filtered, and positively charged molecules being filtered more readily than those with a negative charge. The filtration rate is determined by: The differences in hydrostatic and oncotic pressures between the glomerular capillaries and the lumen of the nephron, the nature of the glomerular basement membrane, and the total glomerular area available for filtration. The total volume of the glomerular filtrate amounts to about 170 L/day, and has a composition similar to plasma except that it is almost free of protein.
Understand the Problem
The passage discusses the factors determining the impermeability of the glomerular filtration barrier, focusing on protein size and charge, as well as specific pressures and membrane properties relevant to filtration in the nephron.
Answer
Differences in pressures, glomerular membrane nature, and filtration area determine the filtration rate.
The filtration rate in the kidneys is determined by differences in hydrostatic and oncotic pressures, the nature of the glomerular basement membrane, and the total glomerular area available for filtration.
Answer for screen readers
The filtration rate in the kidneys is determined by differences in hydrostatic and oncotic pressures, the nature of the glomerular basement membrane, and the total glomerular area available for filtration.
More Information
Filtration selectivity in the kidney is influenced by the molecular size and charge of proteins, with positively charged molecules being more readily filtered.
Tips
A common mistake is to overlook the role of molecular charge in filtration selectivity.
Sources
- Renal Disease - medicine.uodiyala.edu.iq
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