The licensed practitioner has ordered gemcitabine 400 mg/m2 IV for a patient whose BSA is 0.47 m2. You have on hand a 200 mg vial of gemcitabine for injection that contains 38 mg p... The licensed practitioner has ordered gemcitabine 400 mg/m2 IV for a patient whose BSA is 0.47 m2. You have on hand a 200 mg vial of gemcitabine for injection that contains 38 mg per mL. How much medication should this patient receive?
Understand the Problem
The question is asking how to calculate the required dose of gemcitabine for a patient based on their body surface area (BSA). We will first find the total dose using the formula dose = ordered dose per m2 × BSA, and then determine the volume of the solution that contains this total dose using the concentration provided.
Answer
The total dose and volume depend on specific input values for height, weight, ordered dose, and concentration.
Answer for screen readers
The final answer will depend on the values provided for height, weight, ordered dose, and concentration.
Steps to Solve
- Calculate Body Surface Area (BSA)
If not given, you may need to calculate the patient's BSA using the formula:
$$ BSA , (m^2) = \sqrt{\frac{(height , in , cm) \times (weight , in , kg)}{3600}} $$
- Determine Total Dose
Using the ordered dose (in mg/m²), compute the total dose of gemcitabine. This is done by multiplying the ordered dose per m² by the BSA:
$$ \text{Total Dose} = \text{Ordered Dose per } m^2 \times \text{BSA} $$
- Calculate Volume of Solution
Determine the volume needed to deliver the total dose based on the concentration of the solution. The formula is:
$$ \text{Volume (mL)} = \frac{\text{Total Dose (mg)}}{\text{Concentration (mg/mL)}} $$
- Conclusion
Summarize your findings by stating the total dose and the volume of the solution needed for administration.
The final answer will depend on the values provided for height, weight, ordered dose, and concentration.
More Information
Gemcitabine is a chemotherapy drug used to treat various types of cancer, and the dosing is often based on a patient's body surface area, which reflects their metabolism and nutritional status.
Tips
- Forgetting to convert height and weight into the required units for the BSA formula.
- Miscalculating the BSA itself which could lead to an incorrect total dose.
- Not correctly applying the concentration in the volume calculation, leading to dosage errors.
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