Most individuals are heterozygous for MHC genes and therefore express six different class I molecules on every cell, containing α chains encoded by the two inherited alleles of HLA... Most individuals are heterozygous for MHC genes and therefore express six different class I molecules on every cell, containing α chains encoded by the two inherited alleles of HLA-A, B, and C genes.
Understand the Problem
The text discusses the genetic expression of MHC genes in individuals, specifically mentioning heterozygosity and the presence of different class I molecules. It is likely focused on immunogenetics and the role of HLA genes.
Answer
Individuals express six different MHC class I molecules from HLA-A, B, and C genes.
The text explains that most individuals are heterozygous for MHC genes, meaning they have two different alleles for each HLA gene. As a result, they express six different MHC class I molecules from the two alleles of HLA-A, HLA-B, and HLA-C genes.
Answer for screen readers
The text explains that most individuals are heterozygous for MHC genes, meaning they have two different alleles for each HLA gene. As a result, they express six different MHC class I molecules from the two alleles of HLA-A, HLA-B, and HLA-C genes.
More Information
The diversity of MHC molecules is crucial for the immune system's ability to recognize a wide variety of pathogens, as each molecule can present different peptides to T cells.
Tips
Confusing the roles of different MHC classes is common. Class I molecules present peptides to CD8+ T cells, whereas class II present to CD4+ T cells.
Sources
- Major histocompatibility complex - Wikipedia - en.wikipedia.org
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