Molecular and cellular mechanism of action of growth hormone
Understand the Problem
The question is asking for the molecular and cellular mechanisms through which growth hormone exerts its effects in the body. This involves understanding how growth hormone interacts with cells, what receptors are involved, and the signaling pathways activated as a result.
Answer
GH acts via IGF-I, activating tyrosine kinase pathways to enhance metabolism and cell growth.
The actions of growth hormone (GH) are primarily mediated by insulin-like growth factor-I (IGF-I), which activates tyrosine kinase-mediated intracellular signaling pathways, leading to increased metabolism, anabolism, and cellular replication and division.
Answer for screen readers
The actions of growth hormone (GH) are primarily mediated by insulin-like growth factor-I (IGF-I), which activates tyrosine kinase-mediated intracellular signaling pathways, leading to increased metabolism, anabolism, and cellular replication and division.
More Information
Growth hormone, a critical regulator of growth and metabolism, primarily exerts its effects by stimulating IGF-I production, which then activates downstream signaling pathways involved in cellular growth and metabolism.
Tips
A common mistake is to consider GH effects as direct when many actions are mediated through IGF-I.
Sources
- Molecular Mechanisms of Growth Hormone Action - Oxford Academic - academic.oup.com
- The Growth Hormone Receptor: Mechanism of Receptor Activation - Frontiers in Endocrinology - frontiersin.org
- Molecular and Cellular Mechanism of Action of Hormones - SlideShare - slideshare.net
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