In the context of T cell activation, what does the term 'promiscuity of MHC haplotype' refer to?
Understand the Problem
The question is asking for the definition of the term 'promiscuity of MHC haplotype' in the context of T cell activation, with multiple-choice options given. We need to identify the correct answer that fits the definition of this term.
Answer
Ability of MHC molecules to bind diverse antigens.
The term 'promiscuity of MHC haplotype' refers to the ability of certain MHC molecules to bind and present a diverse array of peptide antigens, thus playing a crucial role in T cell recognition and activation.
Answer for screen readers
The term 'promiscuity of MHC haplotype' refers to the ability of certain MHC molecules to bind and present a diverse array of peptide antigens, thus playing a crucial role in T cell recognition and activation.
More Information
This ability is essential for the immune system to recognize a wide variety of pathogens, enhancing the body's defensive capabilities.
Tips
Common mistakes include confusing MHC promiscuity with promiscuity in other contexts or assuming it reduces specificity, whereas it actually refers to versatility in antigen binding.
Sources
- Promiscuity of MHC Class Ib-Restricted T Cell Responses - PMC - ncbi.nlm.nih.gov
- The major histocompatibility complex and its functions - NCBI - ncbi.nlm.nih.gov
- Major Histocompatibility Complex Polymorphism - ScienceDirect.com - sciencedirect.com
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