If you replace the methoxy group in methicillin with an ethoxy group, how will it affect the property of the drug?
Understand the Problem
The question is asking about the implications of substituting a methoxy group with an ethoxy group in the drug methicillin. It seeks to understand how this chemical modification would impact the drug's properties, which may include efficacy, stability, or interactions with bacterial targets.
Answer
Increased resistance to enzymatic hydrolysis.
Replacing the methoxy groups in methicillin with ethoxy groups would increase the resistance to enzymatic hydrolysis by providing larger steric shields, potentially altering the antibiotic’s properties.
Answer for screen readers
Replacing the methoxy groups in methicillin with ethoxy groups would increase the resistance to enzymatic hydrolysis by providing larger steric shields, potentially altering the antibiotic’s properties.
More Information
The increase in size due to the ethoxy group results in larger steric effects, which can interfere with enzymatic degradation processes, potentially making the antibiotic more effective by extending its duration of action.
Tips
A common mistake is assuming the properties remain the same or are significantly better without considering the drug's overall behavior in biological systems.
Sources
- Solved 2. Explain what effect replacing the methoxy groups - Chegg - chegg.com
- Chapter 16: Antibacterial Agents - chem.uwec.edu
- 10889349 Lee Drug Assignment8 - CHAPTER 19 6. REPLACING... - coursehero.com
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